383397-36-2Relevant articles and documents
Metabolism of the host-selective toxins destruxin B and homodestruxin B: Probing a plant disease resistance trait
Pedras, M. Soledade C.,Zaharia, Irina L.,Gai, Yuanzhu,Smith, Kevin C.,Ward, Dale E.
, p. 1655 - 1658 (1999)
(matrix presented). Metabolism of the host-selective toxins destruxin B (1) and homodestruxin B (2) by plants resistant and susceptible to Alternaria blackspot (caused by the fungal pathogen Alternaria brassicae (Berk.) Sacc.) was established using synthetic radiolabeled compounds. The toxins are transformed into the less phytotoxic hydroxydestruxins 3 and 4. The rate of metabolic transformation was correlated with the plant's disease resistance, i.e., significantly faster rates were observed for plants resistant to the pathogen. Efficient syntheses of 1,2,3, and 4 are described.