38377-57-0

Basic information

• Product Name: 2-Cyclopropen-1-one, 2,3-bis(4-methylphenyl)-
• CAS NO: 38377-57-0
• Molecular Formula: C17H14O
• Molecular Weight: 234.298
• Mol File: 38377-57-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Cyclopropen-1-one, 2,3-bis(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropen-1-one, 2,3-bis(4-methylphenyl)-(38377-57-0)
• EPA Substance Registry System: 2-Cyclopropen-1-one, 2,3-bis(4-methylphenyl)-(38377-57-0)

Safety Data

• Hazardous Substances Data: 38377-57-0(Hazardous Substances Data)

Upstream product

• 6262-42-6 1,2,3,3-tetrachlorocyclopropene 
• 108-88-3 toluene 
• 67-66-3 chloroform 
• 2789-88-0 1,2-bis(4-methylphenyl)acetylene 
• 622-47-9 4-tolylacetic acid 
• 70769-70-9 1,3-bis(4-methylphenyl)-2-propanone 
• 501034-28-2 1,3-dibromo-1,3-di-p-tolyl-propan-2-one 
• 77902-60-4 C₁₈H₁₇O⁽¹⁺⁾*BF₄^(1-) 
• 886-38-4 diphenylcyclopropenone 
• 675-09-2 4,6-Dimethyl-2-pyron 
• 104-81-4 4-Methylbenzyl bromide 

Downstream Products

• 73567-97-2 4,4-Dicyan-1,2-bis(p-tolyl)triafulven 
• 77902-60-4 C₁₈H₁₇O⁽¹⁺⁾*BF₄^(1-) 
• 675-09-2 4,6-Dimethyl-2-pyron 
• 886-38-4 diphenylcyclopropenone 
• 73442-24-7 3-Diethylamino-2-phenyl-4,5-di-(p-tolyl)-2,4-cyclopentadien-1-on 
• 15013-77-1 6-phenyl-3,4-di-p-tolyl-pyran-2-one 

Relevant articles and documents

Palladium-Catalyzed C-C Bond Activation of Cyclopropenone: Modular Access to Trisubstituted α,β-Unsaturated Esters and Amides

Strain-driven palladium/N-heterocyclic carbene-catalyzed C-C bond activation of diphenylcyclopropenone (DPC) has been explored for one-step access to trisubstituted α,β-unsaturated esters and amides. The designed transformation works under mild conditions providing exclusively a single stereoisomer. Mechanistic studies support the oxidative addition of the C-C bond of cyclopropenone to in-situ-generated Pd(0) intermediate. We have proved that vinylic hydrogen in the product is coming from phenol/aniline through deuterium-labeling studies. Late-stage functionalization of bioactive molecules such as procaine, estrone, and hymecromone demonstrates the robustness of this protocol.

Lanthanide Silylamide-Catalyzed Synthesis of Pyrano[2,3- b]indol-2-ones

A lanthanide silylamide-catalyzed tandem reaction of isatins, diethyl phosphite, and 2,3-diarylcyclopropenones has been developed. A series of pyrano[2,3-b]indol-2-ones were synthesized in high yields. The cooperation of the Lewis acidity of the lanthanide center and the Bronsted basicity of the N(SiMe3)2 anion may be the key factor affecting the catalytic activity of lanthanide amides.

Cascade Ring-Opening Dual Halogenation of Cyclopropenones with Saturated Oxygen Heterocycles

Represented is a CuX2- or I2-promoted ring-opening dual halogenation of cyclopropenones with saturated oxygen heterocycles, providing an efficient method for the synthesis of 3-haloacrylates. The ring-opening reaction enables the construction of two C–X (X = Cl, Br, or I) bonds and a C–O bond as well as the cleavage of two C–O bonds and a C–C bond in a single step. This protocol is highly atom economical, has an excellent substrate scope, and exhibits the ability for gram-scale reaction.