384-94-1Relevant academic research and scientific papers
Chemoselective Homologation-Deoxygenation Strategy Enabling the Direct Conversion of Carbonyls into (n+1)-Halomethyl-Alkanes
Citarella, Andrea,Holzer, Wolfgang,Ielo, Laura,Langer, Thierry,Miele, Margherita,Pace, Vittorio,Urban, Ernst,Zehl, Martin
supporting information, p. 7629 - 7634 (2020/10/12)
The sequential installation of a carbenoid and a hydride into a carbonyl, furnishing halomethyl alkyl derivatives, is reported. Despite the employment of carbenoids as nucleophiles in reactions with carbon-centered electrophiles, sp3-type alkyl halides remain elusive materials for selective one-carbon homologations. Our tactic levers on using carbonyls as starting materials and enables uniformly high yields and chemocontrol. The tactic is flexible and is not limited to carbenoids. Also, diverse carbanion-like species can act as nucleophiles, thus making it of general applicability.
Copper-catalyzed gem -difluoroolefination of diazo compounds with TMSCF3 via C-F bond cleavage
Hu, Mingyou,He, Zhengbiao,Gao, Bing,Li, Lingchun,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 17302 - 17305 (2014/01/06)
A novel Cu-catalyzed gem-difluoroolefination of diazo compounds is described. This transformation starts from readily available TMSCF3 and diazo compounds, via trifluoromethylation followed by C-F bond cleavage, to afford the desired 1,1-difluoroalkene products.
Fluoroanalogs of DDT: Superacidic BF3-H2O catalyzed facile synthesis of 1,1,1-trifluoro-2,2-diarylethanes and 1,1-difluoro-2,2- diarylethanes
Prakash, G. K. Surya,Paknia, Farzaneh,Mathew, Thomas,Mloston, Gzregorz,Joschek, Jens P.,Olah, George A.
supporting information; experimental part, p. 4128 - 4131 (2011/10/04)
The one-pot synthesis of 1,1,1-trifluoro- and 1,1-difluoro-2,2- diarylethanes from arenes and fluorinated hemiacetals in the BF 3-H2O system is described. The reaction is simple, clean, and convenient, eliminating the use of organic
The Kinetics of Proton and Deuteron Transfer from Ethyl bis-(4-nitrophenyl) Acetate to 1.5-Diazabicyclonon-5-ene in Polar Aprotic Solvents
Schroeder, G.,Jarczewski, A.
, p. 175 - 182 (2007/10/02)
The kinetics and isotope effects of the proton transfer reaction between ethyl bis-(4-nitrophenyl)acetate and 1,5.diazabicyclonon-5-ene in acetonitrile, benzonitrile, dimethyl sulphoxide, N,N-dimethylformamide and hexamethylphosphoramide solvents h
KINETICS, MECHANISM AND DEUTERIUM ISOTOPE EFFECT OF THE REACTION OF 1,1,1-TRIFLUORO-2,2-DI(4-NITROPHENYL)ETHANE WITH SODIUM PHENOLATE IN ALCOHOLS. INFLUENCE OF CROWN ETHERS AND CRYPTANDS
Schroeder, Grzegorz
, p. 181 - 192 (2007/10/02)
The reaction of 1,1,1-trifluoro-2,2-di(4-nitrophenyl)ethane with sodium phenolate in ethanol, n-propanol, iso-propanol, n-butanol, sec-butanol and t-butanol has been investigated. 1-Fluoro-1-phenoxy-2,2-di(4-nitrophenyl)ethane formed from the intermediate
Kinetics, Isotope Effects, and Mechanism of the Reaction of 1,1,1-Trifluoro-2,2-bis-(4-nitrophenyl)ethane with Piperidine and Pyrrolidine Bases in Dipolar Aprotic Solvents
Jarczewski, Arnold,Schroeder, Grzegorz,Dworniczak, Miroslaw
, p. 55 - 60 (2007/10/02)
The kinetics of the reaction of 1,1,1-trifluoro-2,2-bis-(4-nitrophenyl)ethane with piperidine and pyrrolidine bases in a series of solvents are reported.The reaction is complex, le
FLUORAL HEMIACETAL, A NEW REAGENT FOR AROMATIC TRIFLUORO ALKYLATION
Guy, A.,Lobgeois, A.,Lemaire, M.
, p. 361 - 366 (2007/10/02)
α trifluoroalkylation of benzene was carried out in various conditions (catalyst and solvent) by using the readily available fluoral hemiacetal 1 as reagent.The good selectivity observed during the reaction was explained by the HSAB concept.
The kinetics, isotope effects, and mechanism of the reaction of 2,2-di(4-nitrophenyl)-1,1,1-trifluoroethane with alkoxide bases in alcohol solvents
Jarczewski, Arnold,Schroeder, Grzegorz,Galezowski, Wlodzimierz,Leffek, Kenneth T.,Maciejewska, Urszula
, p. 576 - 580 (2007/10/02)
The reaction between 2,2-di(4-nitrophenyl)-1,1,1-trifluoroethane and the alkoxide bases O-CH3, O-C2H5, O-nC4H9, O-CH(CH3)2 and O-C(CH3)3 in their corresponding alcohol solvents is a multistep reaction
