38409-55-1Relevant academic research and scientific papers
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors
Noguchi-Yachide, Tomomi,Aoyama, Atsushi,Makishima, Makoto,Miyachi, Hiroyuki,Hashimoto, Yuichi
, p. 3957 - 3961 (2007)
α-Glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2′-substituted phenylphthalimide skeleton wer
A Synthetic Route to Chiral Benzo-Fused N-Heterocycles via Sequential Intramolecular Hydroamination and Asymmetric Hydrogenation of Anilino-Alkynes
Xu, Cong,Feng, Yu,Li, Faju,Han, Jiahong,He, Yan-Mei,Fan, Qing-Hua
, p. 3979 - 3990 (2019/11/14)
An efficient sequential intramolecular hydroamination/asymmetric hydrogenation reaction under catalysis of a single chiral ruthenium complex or a binary system consisting of achiral gold complex and chiral ruthenium complex has been reported. A diverse range of enantioenriched benzo-fused N-heterocycles, including 1,2,3,4-tetrahydroquinoline, indoline, and 2,3,4,5-tetrahydro-1H-benzo[b]azepine derivatives, were obtained from anilino-alkynes in high yields (up to 98%) with moderate to excellent enantioselectivities (up to 98% ee) under mild conditions. This protocol features good functional group tolerance and high atom economy. Furthermore, this catalytic protocol is applicable to gram-scale synthesis of a naturally occurring alkaloid, (-)-Angustureine.
General access to ortho- and meta-alkylanilines for the synthesis of polyanilines and poly(anilines-co-substituted anilines)
Falcou, Aurélie,Marsacq, Didier,Hourquebie, Patrick,Duchêne, Alain
, p. 225 - 231 (2007/10/03)
Ortho (or meta)-alkylanilines are obtained in good yields by the cross- coupling reaction of ortho(meta)-haloanilines with vinyltins in the presence of palladium catalysts.
Copolymers composed of aniline and alkyl-substituted aniline: Synthesis of ortho-alkylanilines
Falcou,Duchene,Hourquebie
, p. 1213 - 1215 (2007/10/03)
Ortho-alkylanilines are obtained in good yields by cross-coupling reaction of ortho-halogenoanilines with vinyltins in the presence of palladium catalysts.
Para-bromination of ortho-alkyl anilines
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, (2008/06/13)
A process of selectively preparing p-bromo-o-alkylanilines (e.g. 4-bromo-2-methylaniline) by reacting o-alkylanilines (e.g., 2-methylaniline) with unadsorbed bromine in a solvent selected from the group consisting of an inert di- tri- or tetrahaloaliphatic hydrocarbon (e.g., dichloromethane and dibromomethane), an alkyl nitrile (e.g., acetonitrile) and mixtures thereof.
