7023-81-6

Basic information

• Product Name: Ethanone, 2-diazo-1-(3-nitrophenyl)-
• CAS NO: 7023-81-6
• Molecular Formula: C8H5N3O3
• Molecular Weight: 191.146
• Mol File: 7023-81-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-diazo-1-(3-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-diazo-1-(3-nitrophenyl)-(7023-81-6)
• EPA Substance Registry System: Ethanone, 2-diazo-1-(3-nitrophenyl)-(7023-81-6)

Safety Data

• Hazardous Substances Data: 7023-81-6(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 121-90-4 m-nitrobenzoic acid chloride 
• 121-92-6 3-nitrobenzoic acid 
• 154669-16-6 3-(3-nitro-phenyl)-3-oxo-propionaldehyde 
• 5000-63-5 C₈H₇NO₅ 
• 121-89-1 3-Nitroacetophenone 
• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 3058-37-5 (Z)-potassium methanediazotate 

Downstream Products

• 90945-65-6 2-acetoxy-1-(3-nitrophenyl)ethanone 
• 94574-34-2 2-methyl-N-[4-(3-nitro-benzoyl)-[1,2,3]thiadiazol-5-yl]-benzamide 
• 21443-53-8 C,C'-bis-(3-nitro-phenyl)-C,C'-(2-oxy-furazan-3,4-diyl)-bis-methanone 
• 74048-11-6 2-methyl-5-(3-nitro-phenyl)-oxazole 
• 145930-40-1 5-(3-nitrophenyl)-2-phenyloxazole 
• 14318-64-0 ethyl (3-nitrophenyI)acetate 
• 1877-73-2 3-nitro-benzeneacetic acid 
• 38411-41-5 (3-nitrophenyl)acetyl chloride 
• 860651-00-9 C₁₄H₇ClF₃N₃O₂ 
• 1477503-75-5 N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)acetamide 
• 1477503-76-6 N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide 
• 1477503-77-7 N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide 
• 860785-05-3 C₁₄H₉ClF₃N₃ 

Relevant articles and documents

Facile access to 2,2-disubstituted indolin-3-ones: Via a cascade Fischer indolization/Claisen rearrangement reaction

An efficient approach for the synthesis of 2,2-disubstituted indolin-3-ones is described. From readily accessible aryl hydrazines and allyloxyketones, 2,2-disubstituted indolin-3-ones could be obtained in good to excellent yields under mild reaction condi

Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists

In this study, a series of fused-heterocyclic derivatives were systematically designed and synthesized using an efficient route, and evaluated in terms of GLP-1R agonist activity. We employed short synthetic steps and reactions that are tolerant of the presence of various functional groups and suitable for parallel operations to enable the rapid generation of libraries of diverse and structurally complex small molecules. Of the compounds synthesized, 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a] pyridin-2-yl)phenyl methanesulfonate (8e) was the most potent agonist with an EC50 of 7.89 μM, and thus is the compound with the greatest potential for application. These findings represent a valuable starting point for the design and discovery of small-molecule GLP-1R agonists that can be administered orally.

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.