3851-87-4Relevant articles and documents
Cu-Catalyzed Alkylarylation of Vinylarenes with Masked Alkyl Electrophiles
Zhu, Xiaotao,Su, Muqiao,Zhang, Qi,Li, Yajun,Bao, Hongli
supporting information, p. 620 - 625 (2020/01/02)
A Cu-catalyzed synthesis of a range of value-Added 1,1-diarylalkanes by radical alkylarylation of vinylarenes with alkyl peroxides as masked alkyl electrophiles is reported. The reaction features broad substrate scope, good functional group tolerance, and mild reaction conditions. Various bioactive molecules and key pharmaceutical intermediates have been easily synthesized by this method, demonstrating its synthetic value.
Synthesis method of diacyl peroxide
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Paragraph 0057-0076, (2019/02/26)
The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of diacyl peroxide. The synthesis method comprises the following steps: adding an acyl compound, hydrogen peroxide and a polyvinyl alcohol composite amino acid catalyst into an organic solvent, and performing a dehydration reaction while stirring to synthesize the diacyl peroxide, wherein the polyvinyl alcohol composite amino acid catalyst is obtained by polymerizing a spherical polyvinyl alcohol matrix and composite amino acid. Use of an expensive chemical raw material, namely acyl chloride, is avoided in the peroxide production process, a synthesis technology of the peroxide is optimized, and discharge of chloride-containing wastewater/waste solid in the industrial production process is reduced.
Copper(I)-catalyzed tandem reaction: Synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes
Israr, Muhammad,Ye, Changqing,Muhammad, Munira Taj,Li, Yajun,Bao, Hongli
supporting information, p. 2916 - 2922 (2018/12/13)
A copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported. The alkyl carboxylic acids is for the first time being used as the alkyl azide precursors in the form of alkyl diacyl peroxides. This method avoids the necessity to handle organic azides, as they are generated in situ, making this protocol operationally simple. The Cu(I) catalyst not only participates in the alkyl diacyl peroxides decomposition to afford alkyl azides but also catalyzes the subsequent CuAAC reaction to produce the 1,2,3-triazoles.