38557-82-3

Basic information

• Product Name: isonicotinamide 1-oxide
• Synonyms: 1-oxidopyridin-1-ium-4-carboxamide;isonicotinamide 1-oxide;1-Oxide Isonicotinamide;4-Pyridinecarboxamide 1-Oxide;Isonicotinamide N-Oxide;NSC 18386;4-Pyridinecarboxamide,1-oxide(9CI);4-Carbamoylpyridine 1-oxide
• CAS NO: 38557-82-3
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.12404
• EINECS: 253-998-7
• Product Categories: AMIDE;Chemical Amines;Amines;Heterocycles;Nitric Oxide Reagents
• Mol File: 38557-82-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 286-290°C (dec.)
• Boiling Point: 514.7°Cat760mmHg
• Flash Point: 265.1°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 1.05E-10mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Water (Slightly)
• CAS DataBase Reference: isonicotinamide 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: isonicotinamide 1-oxide(38557-82-3)
• EPA Substance Registry System: isonicotinamide 1-oxide(38557-82-3)

Safety Data

• Hazardous Substances Data: 38557-82-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow Solid

Uses

4-Pyridinecarboxamide 1-Oxide (cas# 38557-82-3) is a compound useful in organic synthesis.

InChI:InChI=1/C6H6N2O2/c7-6(9)5-1-3-8(10)4-2-5/h1-4H,(H2,7,9)

Upstream product

• 1003-67-4 4-methylpyridine-1-oxide 
• 1570-45-2 isonicotinic acid ethylester 
• 14906-59-3 4-cyanopyridine N-oxide 
• 91-66-7 N,N-diethylaniline 
• 24145-29-7 (E)-4-pyridinecarbaldehyde 1-oxide oxime 
• 24145-27-5 (Z)-(1-oxidopyridin-1-ium-4-yl)-4-carbaldoxime 
• 100-48-1 pyridine-4-carbonitrile 
• 1453-82-3 isonicotinamide 
• 14906-37-7 ethyl isonicotinate N-oxide 

Downstream Products

• 125230-39-9 1-(4-Chloro-phenyl)-3-(1-oxy-pyridine-4-carbonyl)-urea 
• 121779-83-7 C₂₇H₂₂N₆O₄S₂ 
• 121779-89-3 1-Oxy-N-[3-phenyl-thiazolidin-(2Z)-ylidene]-isonicotinamide 
• 1279114-11-2 C₆H₆N₂O₂*C₁₂H₁₁ClN₂O₅S 
• 63919-16-4 Thioisonicotinamid-1-oxid 
• 91447-89-1 2-chloropyridine-4-carbothioamide 
• 1453-82-3 isonicotinamide 
• 3731-53-1 4-(aminomethyl)pyridine 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 14906-59-3 4-cyanopyridine N-oxide 

Relevant articles and documents

Organic synthesis via magnetic attraction: Benign and sustainable protocols using magnetic nanoferrites

Magnetic nano-catalysts have been prepared using simple modification of iron ferrites. The nm size range of these particles facilitates the catalysis process, as an increased surface area is available for the reaction; the easy separation of the catalysts by an external magnet and their recovery and reuse are additional beneficial attributes. Glutathione bearing nano-ferrites have been used as organocatalysts for the Paal-Knorr reaction and homocoupling of boronic acids. Nanoferrites, post-synthetically modified by ligands, were used to immobilize nanometals (Cu, Pd, Ru, etc.) which enabled the development of efficient, sustainable and green procedures for azide-alkynes-cycloaddition (AAC) reactions, C-S coupling, O-allylation of phenol, Heck-type reactions and hydration of nitriles.

FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.

ELUCIDATION OF THE REACTION PATH FOR THE NITROSATION OF 2- AND 4-METHYLPYRIDINE 1-OXIDES WITH ALKYL NITRITE IN LIQUID AMMONIA

The reaction path for the nitrosation of 2- and 4-methylpyridine 1-oxides with alkyl nitrite in the presence of NaNH2 in liquid NH3 was elucidated experimentally, and theoretically by the use of a semiempirical molecular orbital method (PM3 method).In the case of the nitrosation of 4-methylpyridine 1-oxide at room temperature, only 4-pyridinecarboxamide 1-oxide was obtained, while at -33 deg C a thermodynamically unstable aldoxime, (Z)-4-pyridinecarbaldehyde 1-oxide oxime, which was easily transformed into E-form by heating, was obtained.On the other hand, the nitrosation of 2-methylpyridine 1-oxide gave only a thermodynamically stable aldoxime, (E)-2-pyridinecarbaldehyde 1-oxide oxime, both at room temperature and at -33 deg C.These results were reasonably explained by PM3 method.