3204-73-7

Basic information

• Product Name: 4-(2-HYDROXYETHOXY)BENZOIC ACID METHYL ESTER
• Synonyms: 4-(2-hydroxyethoxy)-benzoicacimethylester;RARECHEM AL BF 0433;METHYL 4-(2-HYDROXYETHOXY)BENZOATE;4-(2-HYDROXYETHOXY)BENZOIC ACID METHYL ESTER;AKOS B030709;4-(2-Hydroxyethoxy)benzoic acid methyl ester,98%;Hydroxyethoxybenzoicacidmethylester,98%;methyl p-(2-hydroxyethoxy)benzoate
• CAS NO: 3204-73-7
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.2
• EINECS: 221-708-8
• Product Categories: Aromatic Esters
• Mol File: 3204-73-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 66°C
• Boiling Point: 336.5°C at 760 mmHg
• Flash Point: 132.6°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 4.38E-05mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(2-HYDROXYETHOXY)BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-HYDROXYETHOXY)BENZOIC ACID METHYL ESTER(3204-73-7)
• EPA Substance Registry System: 4-(2-HYDROXYETHOXY)BENZOIC ACID METHYL ESTER(3204-73-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-52-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 3204-73-7(Hazardous Substances Data)

Usage

General Description

4-(2-Hydroxyethoxy)benzoic acid methyl ester, also known as HG-DME or methyl 4-(2-hydroxyethoxy)benzoate, is a chemical compound commonly used in the production of sunscreen and other personal care products. It is an ester formed from the reaction of 4-(2-hydroxyethoxy)benzoic acid and methanol. 4-(2-HYDROXYETHOXY)BENZOIC ACID METHYL ESTER is used as a UV filter in sunscreens due to its ability to absorb and block harmful UVA and UVB rays from the sun. It is also used in other cosmetic products for its ability to provide protection from the sun's damaging effects. Additionally, it has some antimicrobial properties, making it useful in certain skin care formulations. Despite its benefits, there is ongoing research to understand potential side effects and risks associated with its use.

InChI:InChI=1/C10H12O4/c1-13-10(12)8-2-4-9(5-3-8)14-7-6-11/h2-5,11H,6-7H2,1H3

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 107-07-3 2-chloro-ethanol 
• 5026-62-0 sodium methylparaben 
• 540-51-2 2-bromoethanol 
• 67-56-1 methanol 
• 22042-73-5 4-(2-hydroxy-ethoxy)-benzaldehyde 
• 15149-10-7 2-(4-methylphenoxy)ethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 102196-18-9 2-(4-(hydroxymethyl)phenoxy)ethanol 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 38567-00-9 4-(2-Chloroethoxy)benzoic acid methyl ester 
• 60893-68-7 methyl 4-(2-methoxyethoxy)benzoate 
• 1056555-55-5 (4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)methanol 

Relevant articles and documents

Novel chemoselective 18F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective 18F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes

A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.

COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS

The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.