38667-55-9

Basic information

• Product Name: 2-METHYL-PARA-AMINOBENZOICACID
• Synonyms: 2-METHYL-PARA-AMINOBENZOICACID;4-(acetylamino)-2-chlorobenzoic acid(SALTDATA: FREE);4-(acetylamino)-2-chlorobenzoic acid;4-acetamido-2-chlorobenzoic acid
• CAS NO: 38667-55-9
• Molecular Formula: C₉H₈ClNO₃
• Molecular Weight: 213.62
• Mol File: 38667-55-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 444.9°C at 760 mmHg
• Flash Point: 222.9°C
• Appearance: /
• Density: 1.453g/cm³
• Vapor Pressure: 1.07E-08mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2-METHYL-PARA-AMINOBENZOICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-PARA-AMINOBENZOICACID(38667-55-9)
• EPA Substance Registry System: 2-METHYL-PARA-AMINOBENZOICACID(38667-55-9)

Safety Data

• Hazardous Substances Data: 38667-55-9(Hazardous Substances Data)

Usage

General Description

2-Methyl-para-aminobenzoic acid is a chemical compound that belongs to the class of para-aminobenzoic acids, which are organic compounds containing a benzene ring with a para-aminobenzoic acid moiety. It is derived from the amino acid tyrosine and can be found in a variety of sunscreen and cosmetic products as an ingredient that helps protect the skin from the harmful effects of ultraviolet (UV) radiation. It works by absorbing and reflecting UV rays, thus helping to prevent sunburn and other forms of skin damage. Additionally, 2-methyl-para-aminobenzoic acid exhibits some antioxidant properties and has been studied for its potential use in the treatment of various skin conditions. However, it is important to note that this chemical may cause allergic reactions in some individuals and should be used with caution.

InChI:InChI=1/C9H8ClNO3/c1-5(12)11-6-2-3-7(9(13)14)8(10)4-6/h2-4H,1H3,(H,11,12)(H,13,14)

Upstream product

• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 75-36-5 acetyl chloride 
• 95-74-9 3-chloro-p-toluidine 
• 588-07-8 3-Chloroacetanilide 
• 103273-72-9 acetic acid-(4-acetyl-3-chloro-anilide) 
• 7149-79-3 N-(3-chloro-4-methylphenyl)acetamide 
• 7664-93-9 sulfuric acid 
• 90798-26-8 acetic acid-(3-chloro-4-chloroacetyl-anilide) 
• 7487-88-9 magnesium sulfate 
• 69828-55-3 N-(3-chloro-4-formylphenyl)acetamide 

Downstream Products

• 16017-69-9 ethyl-2-chloro-4-amino-benzoate 
• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 42832-87-1 3,6-diaminoacridin-9(10H)-one 
• 857612-73-8 1,6-diamino-10H-acridin-9-one 
• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 50270-08-1 4-acetylamino-2-chloro-5-nitro-benzoic acid 
• 857550-00-6 4-acetylamino-2-(4-acetylamino-anilino)-benzoic acid 
• 52156-62-4 2,6-diamino-9(10H)-acridone 
• 100038-98-0 4-Acetylamino-2-(2-methoxycarbonyl-phenylamino)-benzoic acid 
• 857549-95-2 4-acetylamino-2-(3-amino-anilino)-benzoic acid 
• 86026-75-7 N(3'-nitrophenyl)-4-acetylaminoanthranilic acid 

Relevant articles and documents

Proliferation inhibition of novel diphenylamine derivatives

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs in the world but some NSAIDs such as diclofenac and tolfenamic acid display levels of cytotoxicity, an effect which has been attributed to the presence of diphenylamine contained in their structures. A novel series of diphenylamine derivatives were synthetised and evaluated for their cytotoxic activities and proliferation inhibition. The most active compounds in the cytotoxicity tests were derivative 6g with an IC50 value of 2.5 ± 1.1 × 10?6 M and derivative 6f with an IC50 value of 6.0 ± 3.0 × 10?6 M (L1210 cell line) after 48 h incubation. The results demonstrate that leukemic L1210 cells were much more sensitive to compounds 6f and 6g than the HEK293T cells (IC50 = 35 × 10?6 M for 6f and IC50 > 50 × 10?6 M for 6g) and NIH-3T3 (IC50 > 50 × 10?6 M for both derivatives). The IC50 values show that these substances may selectively kill leukemic cells over non-cancer cells. Cell cycle analysis revealed that a primary trend of the diphenylamine derivatives was to arrest the cells in the G1-phase of the cell cycle within the first 24 h. UV–visible, fluorescence spectroscopy and circular dichroism were used in order to study the binding mode of the novel compounds with DNA. The binding constants determined by UV–visible spectroscopy were found to be in the range of 2.1–8.7 × 104 M?1. We suggest that the observed trend for binding constant K is likely to be a result of different binding thermodynamics accompanying the formation of the complexes.

Substituted benzimidazoles and imidazo-[4,5]-pyridines

2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.