386715-33-9

Basic information

• Product Name: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)
• Synonyms: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI);2-(trifluoromethyl)-5-chloromethyl pyridine;5-(Chloromethyl)-2-(trifluoromethyl)pyridine97%;Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)-
• CAS NO: 386715-33-9
• Molecular Formula: C₇H₅ClF₃N
• Molecular Weight: 195.5695096
• Product Categories: HALOMETYL
• Mol File: 386715-33-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 110°C/19mm
• Flash Point: 77.746 °C
• Appearance: /
• Density: 1.359 g/cm³
• Vapor Pressure: 0.367mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)(386715-33-9)
• EPA Substance Registry System: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)(386715-33-9)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 386715-33-9(Hazardous Substances Data)

Usage

General Description

Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) is a chemical compound with the molecular formula C8H6ClFN2. It is a derivative of pyridine, with a chloromethyl group and a trifluoromethyl group attached to the 5 and 2 positions, respectively. Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It also has applications in the production of specialty chemicals and materials. Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) is a versatile and valuable chemical with diverse industrial uses.

InChI:InChI=1/C7H5ClF3N/c8-3-5-1-2-6(12-4-5)7(9,10)11/h1-2,4H,3H2

Upstream product

• 386704-12-7 6-(trifluoromethyl)pyridine-3-carbaldehyde 
• 386704-04-7 6-(trifluoromethyl)pyridin-3-ylmethanol 
• 221313-10-6 methyl 6-(trifluoromethyl)pyridine-3-carboxylate 
• 231291-22-8 6-trifluoromethylnicotinic acid 

Downstream Products

• 765298-04-2 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile 
• 2107987-82-4 O-ethyl S-((6-(trifluoromethyl)pyridin-3-yl)methyl)carbonodithioate 
• 1417742-87-0 4-(1-(6-((6-(trifluoromethyl)pyridin-3-yl)methyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoic acid 
• 946578-00-3 sulfoxaflor 
• 1359980-18-9 3-[6-chloro-2-methyl-1-(6-trifluoromethyl-pyridin-3-ylmethyl)-1H-indol-3-ylsulfanyl]-benzoic acid methyl ester 
• 917969-43-8 8-bromo-7-(4-chlorophenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 

Relevant articles and documents

Sulfoxaflor hapten, preparation method thereof, antigen, antibody and application thereof

The invention provides a sulfoxaflor hapten, a method for preparing the hapten, a sulfoxaflor antigen obtained by coupling the hapten with carrier protein, a sulfoxaflor antibody obtained by immunizing animals with the sulfoxaflor antigen, and applications of the sulfoxaflor hapten, the antigen and the antibody in immunological detection. The invention further discloses a sulfoxaflor colloidal gold chromatography detection device prepared from the sulfoxaflor hapten and a method for detecting sulfoxaflor in a sample by using the sulfoxaflor colloidal gold chromatography detection device. According to the preparation method provided by the invention, used chemical reagents are easy to obtain, the operation process is simple, the reaction yield is relatively high, and the detection cost is relatively low. The detection device provided by the invention can rapidly and accurately detect the residual content of sulfoxaflor in vegetables or fruits, and can meet the requirements of supervision departments and detection organizations for on-site supervision and law enforcement. The detection method provided by the invention has the advantages of high sensitivity, strong specificity, low cost, simple operation, short detection time and long shelf life.

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

NITROGEN-CONTAINING HETEROCYCLIC ALKENYL COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL AND ORGANIC SEMICONDUCTOR DEVICE

PROBLEM TO BE SOLVED: To provide a compound that is high in charge transfer and atmosphere stability and is suitable for an organic semiconductor material, provide an organic semiconductor material comprising the compound, and provide an organic semiconductor element comprising the organic semiconductor material. SOLUTION: The present invention provides a compound represented by formula (1), specifically a compound represented by formula (2) (Ar1 is an unsaturated cyclic hydrocarbon group or the like; Ar2 is an unsaturated heterocyclic group containing nitrogen with an unshared electron pair, or the like; B is -CH=CH- or -C≡C-; X11-X13 independently represent C-R or N; at least one of X12 and X13 is N). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT