386715-33-9

Usage

Uses

Used in Pharmaceutical Industry:
Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and functional groups make it a valuable building block for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)(9CI) serves as an essential intermediate for the production of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection.
Used in Specialty Chemicals Production:
Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)(9CI) is utilized as a precursor in the synthesis of specialty chemicals. Its unique properties allow for the creation of high-performance materials with specific applications in various industries.
Used in Material Science:
In the field of material science, Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)(9CI) is employed in the development of advanced materials with tailored properties. Its versatility and reactivity contribute to the creation of innovative materials for diverse applications, such as sensors, catalysts, and coatings.

InChI:InChI=1/C7H5ClF3N/c8-3-5-1-2-6(12-4-5)7(9,10)11/h1-2,4H,3H2

Upstream product

• 386704-12-7 6-(trifluoromethyl)pyridine-3-carbaldehyde 
• 386704-04-7 6-(trifluoromethyl)pyridin-3-ylmethanol 
• 221313-10-6 methyl 6-(trifluoromethyl)pyridine-3-carboxylate 
• 231291-22-8 6-trifluoromethylnicotinic acid 

Downstream Products

• 765298-04-2 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile 
• 2107987-82-4 O-ethyl S-((6-(trifluoromethyl)pyridin-3-yl)methyl)carbonodithioate 
• 1417742-87-0 4-(1-(6-((6-(trifluoromethyl)pyridin-3-yl)methyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoic acid 
• 946578-00-3 sulfoxaflor 
• 1359980-18-9 3-[6-chloro-2-methyl-1-(6-trifluoromethyl-pyridin-3-ylmethyl)-1H-indol-3-ylsulfanyl]-benzoic acid methyl ester 
• 917969-43-8 8-bromo-7-(4-chlorophenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 

Relevant academic research and scientific papers

Sulfoxaflor hapten, preparation method thereof, antigen, antibody and application thereof

The invention provides a sulfoxaflor hapten, a method for preparing the hapten, a sulfoxaflor antigen obtained by coupling the hapten with carrier protein, a sulfoxaflor antibody obtained by immunizing animals with the sulfoxaflor antigen, and applications of the sulfoxaflor hapten, the antigen and the antibody in immunological detection. The invention further discloses a sulfoxaflor colloidal gold chromatography detection device prepared from the sulfoxaflor hapten and a method for detecting sulfoxaflor in a sample by using the sulfoxaflor colloidal gold chromatography detection device. According to the preparation method provided by the invention, used chemical reagents are easy to obtain, the operation process is simple, the reaction yield is relatively high, and the detection cost is relatively low. The detection device provided by the invention can rapidly and accurately detect the residual content of sulfoxaflor in vegetables or fruits, and can meet the requirements of supervision departments and detection organizations for on-site supervision and law enforcement. The detection method provided by the invention has the advantages of high sensitivity, strong specificity, low cost, simple operation, short detection time and long shelf life.

SPIRO COMPOUNDS AS GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, L, Z, Q1, Q2 and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

Modular Route to Azaindanes

A convergent radical based route to azaindanes is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-ethyl dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization.

NITROGEN-CONTAINING HETEROCYCLIC ALKENYL COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL AND ORGANIC SEMICONDUCTOR DEVICE

PROBLEM TO BE SOLVED: To provide a compound that is high in charge transfer and atmosphere stability and is suitable for an organic semiconductor material, provide an organic semiconductor material comprising the compound, and provide an organic semiconductor element comprising the organic semiconductor material. SOLUTION: The present invention provides a compound represented by formula (1), specifically a compound represented by formula (2) (Ar1 is an unsaturated cyclic hydrocarbon group or the like; Ar2 is an unsaturated heterocyclic group containing nitrogen with an unshared electron pair, or the like; B is -CH=CH- or -C≡C-; X11-X13 independently represent C-R or N; at least one of X12 and X13 is N). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Composition

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Composition

MODULATORS OF TOLL-LIKE RECEPTORS

Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.