38678-58-9 Usage
Description
PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is a chemical compound that serves as a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a reactive ester derivative of phenoxyacetic acid and N-hydroxysuccinimide, which enables the conjugation of proteins and peptides through amide bond formation. Known for its stability and compatibility with a wide range of solvents, it is a valuable tool in chemical synthesis and bioconjugation reactions.
Uses
Used in Pharmaceutical and Agrochemical Synthesis:
PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as an intermediate for the synthesis of various pharmaceuticals and agrochemicals, facilitating the creation of new compounds with potential therapeutic and agricultural applications.
Used in Bioconjugation:
PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a bioconjugation agent for the attachment of proteins and peptides through amide bond formation, enabling the development of novel bioconjugates for research and medical applications.
Used in Peptide Synthesis:
In the field of peptide synthesis, PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a coupling agent to facilitate the formation of peptide bonds, allowing for the efficient synthesis of peptides with specific biological activities.
Used in Biomolecule Modification:
PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a modifying agent for the functionalization of biomolecules, such as proteins, nucleic acids, and carbohydrates, to enhance their properties or introduce new functionalities for various research and medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 38678-58-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,6,7 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 38678-58:
(7*3)+(6*8)+(5*6)+(4*7)+(3*8)+(2*5)+(1*8)=169
169 % 10 = 9
So 38678-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H11NO5/c14-10-6-7-11(15)13(10)18-12(16)8-17-9-4-2-1-3-5-9/h1-5H,6-8H2
38678-58-9Relevant articles and documents
Gillam et al.
, p. 3459,3460 (1968)
REACTIVITY OF N-HYDROXYSUCCINIMIDE ESTERS
Stefanowicz, P.,Siemion, I. Z.
, p. 111 - 118 (2007/10/02)
The reactions of N-hydroxysuccinimide esters (OSu-esters) of benzyloxycarbonylamino acids and of simple carboxylic acid with p-anisidine in DMSO were studied kinetically at various temperatures.Activation parameters ΔH++ and ΔS++ for these data were determined.The rate constants for aminolysis of carboxylic acid esters fit the two-parameter Taft equation with reaction constants equal: ρ* = 1.08 and ρs = 1.1.The activation entropies are in the range -121.8 - -180.0 J/deg M.Transition state in these reactions is tetrahedral and zwitter ionic, in agreementwith the mechanism given by Cline and Hanna for aminolysis of succinimidyl benzoates.
Synthesis of analogs of D-Ala-D-Ala as potential inhibitors of bacterial cell wall biosynthesis
Hagen,Bergan,Aasen
, p. 5 - 14 (2007/10/02)
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