387354-06-5

Upstream product

• 1128-54-7 3-methyl-1-phenyl-1H-pyrazole 
• 768-33-2 phenyldimethylsilyl chloride 
• 460095-29-8 3-methyl-5-dimethylphenylsilylisoxazole 

Downstream Products

• 89-25-8 edaravone 
• 387353-94-8 5-(fluoro-dimethylsilanyl)-3-methyl-1-phenyl-1H-pyrazole 

Relevant academic research and scientific papers

Silylated β-enaminones as precursors in the regioselective synthesis of silyl pyrazoles

Silyl β-enaminones have been synthesized by reductive cleavage of 5-silyl, 3-, 4- and 5-silylmethylisoxazoles.These versatile synthons bearing different silyl groups in various positions of the enaminoketonic system are of great interest in the regioselec

Synthesis and reactions of silylated and stannylated 1,2-azoles

Silicon or tin 4-metalated pyrazoles and isoxazoles are synthesized by silyl- or stannylcupration from 4-haloazoles. On the other hand, 5-metalated pyrazoles are prepared by reaction of 5-un-substituted pyrazoles with LDA and subsequent treatment with chlorosilanes and chlorostannanes. Furthermore, starting from 5-unsubstituted 4-halopyrazoles and applying both methodologies, 4,5-dimetalated pyrazoles bearing silyl groups different from trimethylsilyl or tributylstannyl groups are obtained. Some regioselective ipso-substitutions are also studied.