460095-29-8

Upstream product

• 23183-95-1 1-dimethylphenylsilyl-2-trimethylsilylacetylene 
• 768-33-2 phenyldimethylsilyl chloride 
• 263914-93-8 4-(dimethyl(phenyl)silyl)but-3-yn-2-one 

Downstream Products

• 387354-06-5 3-methyl-5-(dimethylphenylsilyl)-1-phenylpyrazole 
• 387354-05-4 1,3-dimethyl-5-(dimethylphenylsilyl)pyrazole 

Relevant academic research and scientific papers

Cycloisomerization of acetylenic oximes and hydrazones under gold catalysis: Synthesis and cytotoxic evaluation of isoxazoles and pyrazoles

The synthesis of substituted isoxazoles and pyrazoles through a general cycloisomerization methodology has been reported. The capability of gold(III) chloride to promote cycloisomerization of both α, β-acetylenic oximes and α, β-acetylenic hydrazones is t

Regiospecific synthesis of 5-silyl azoles

5-Silylisoxazoles bearing other silyl groups different to the more usual trimethylsilyl have been prepared by condensation of silylalkynones with hydroxylamine hydrochloride. The reaction with hydrazines is more complex and leads to 5-silylpyrazoles or the corresponding hydrazones, which can be cyclized by reaction with electrophiles. This has allowed us to synthesize 5-silylpyrazoles functionalized at C-4 by groups impossible to introduce by electrophilic substitution of the pyrazole nucleus.