38895-88-4

Basic information

• Product Name: 1-HYDROXY-3,3-DIMETHYLBUTAN-2-ONE
• Synonyms: 1-HYDROXY-3,3-DIMETHYLBUTAN-2-ONE
• CAS NO: 38895-88-4
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.15828
• EINECS: -0
• Mol File: 38895-88-4.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
• Stability: Volatile
• CAS DataBase Reference: 1-HYDROXY-3,3-DIMETHYLBUTAN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXY-3,3-DIMETHYLBUTAN-2-ONE(38895-88-4)
• EPA Substance Registry System: 1-HYDROXY-3,3-DIMETHYLBUTAN-2-ONE(38895-88-4)

Safety Data

• Hazardous Substances Data: 38895-88-4(Hazardous Substances Data)

Usage

Uses

1-Hydroxy-3,3-dimethylbutan-2-one can be used for catalysis reactions.

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 13547-70-1 1-chloro-3,3-dimethyl-butan-2-one 
• 558-37-2 tert-butylethylene 
• 112392-77-5 ((3,3-dimethylbut-1-en-2-yl)oxy)dimethylsilanol 
• 112392-89-9 3,3-dimethyl-2-(chlorodimethylsiloxy)-1-butene 
• 7732-18-5 water 
• 5469-26-1 1-Bromopinacolon 
• 22502-84-7 4-(1-t-butylethenyl)morpholine 
• 17510-46-2 3,3-dimethyl-2-(trimethylsilyl)oxy-1-butene 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 
• 38559-25-0 acetic acid 3,3-dimethyl-2-oxobutyl ester 

Downstream Products

• 815-17-8 trimethylpyruvic acid 
• 893412-73-2 MDI-101 
• 112245-13-3 (S)-tert-leucinol 

Relevant articles and documents

Preparation method of hydroxyl pinacolone retinoate

The invention provides a preparation method of hydroxyl pinacolone retinoate. The preparation method comprises the following steps: preparing corresponding pinacolone by using chloropinacolone through hydrolysis reaction under a strong alkaline condition, and then carrying out condensation reaction on the pinacolone and tretinoin under the conditions of a condensing agent and a catalyst to obtain the hydroxyl pinacolone retinoate. The method is easy to operate, high in reaction yield and suitable for industrial application, and the product obtained through the reaction is free of chloro-pinacolone impurities and can meet the requirement of cosmetics for the quality of the chloro-pinacolone. The invention further provides a novel crystal form of the hydroxyl pinacolone retinoate, and the crystal form is good in stability.

Distal Functional Group Migration for Visible-light Induced Carbo-difluoroalkylation/monofluoroalkylation of Unactivated Alkenes

A general and practical protocol for elusive carbo-difluoroalkylation/ monofluoroalkylation of unactivated alkenes based on the distal functional group migration is described. A portfolio of functional groups including heteroaryl, imino, formyl, and alkynyl groups showcase the migratory aptitude. In combination with visible-light photocatalysis, a broad range of di- and mono-fluorinated alkyl ketones are readily obtained in synthetically useful yields under mild reaction conditions. (Figure presented.).

Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents

The functionalization of carbonyl compounds in the α-position has gathered much attention as a synthetic route because of the wide biological importance of such products. Through polarity reversal, or "umpolung", we show here that typical nucleophiles, such as oxygen, nitrogen, and even carbon nucleophiles, can be used for addition reactions after tethering them to enol ethers. Our findings allow novel retrosynthetic planning and rapid assembly of structures previously accessible only by multistep sequences. A Nu approach: An efficient α-functionalization of ketones with a range of simple and useful nucleophiles is possible by using hypervalent iodine reagents (see scheme; Nu′ can be the Nu itself or a protected form of this nucleophile group).