38895-95-3

Basic information

• Product Name: 1-Propanone, 2,3-dibromo-3-(4-chlorophenyl)-1-phenyl-
• CAS NO: 38895-95-3
• Molecular Formula: C15H11Br2ClO
• Molecular Weight: 402.513
• Mol File: 38895-95-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2,3-dibromo-3-(4-chlorophenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2,3-dibromo-3-(4-chlorophenyl)-1-phenyl-(38895-95-3)
• EPA Substance Registry System: 1-Propanone, 2,3-dibromo-3-(4-chlorophenyl)-1-phenyl-(38895-95-3)

Safety Data

• Hazardous Substances Data: 38895-95-3(Hazardous Substances Data)

Upstream product

• 24721-26-4 4-chlorochalcone 
• 98-86-2 acetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 131138-45-9 1-[3-(4-Chloro-phenyl)-5-hydroxy-5-phenyl-4,5-dihydro-pyrazol-1-yl]-2-(naphthalen-2-yloxy)-ethanone 
• 131138-43-7 [3-(4-Chloro-phenyl)-5-hydroxy-5-phenyl-4,5-dihydro-pyrazol-1-yl]-(2-hydroxy-phenyl)-methanone 
• 24721-26-4 4-chlorochalcone 
• 30152-32-0 3-(4?'-chlorophenyl)-5-phenyl-1H-pyrazole 
• 84374-74-3 6-(4-Chloro-phenyl)-4-phenyl-1,6-dihydro-pyrimidine-2,5-dithione 
• 84374-80-1 6-(4-Chloro-phenyl)-4-phenyl-1,6-dihydro-pyrimidine-2,5-dione 
• 95734-25-1 Acetic acid 6-(4-chloro-phenyl)-3,4-diphenyl-pyridin-2-yl ester 
• 74990-19-5 5-(4-Chloro-phenyl)-1,3-diphenyl-1,5-dihydro-pyrazole-4-thione 
• 74990-08-2 5-(4-Chloro-phenyl)-1,3-diphenyl-1,5-dihydro-pyrazol-4-one 
• 147623-04-9 8-(4-Chloro-phenyl)-1,3-dimethyl-6-phenyl-1,9-dihydro-pyrimido[4,5-b][1,4]diazepine-2,4-dione 
• 62056-15-9 3-(4-chlorophenyl)-1-phenylpropan-1-ol 
• 5739-39-9 3-(4-chlorophenyl)-1-phenylpropan-1-one 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 57038-83-2 2-bromo-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 

Relevant articles and documents

Modular access to 1,2-allenyl ketones based on a photoredox-catalysed radical-polar crossover process

Herein, a new protocol dealing with the preparation of 1,2-allenyl ketones has been successfully developedviathe reactions of enynes with radicals enabled by dual photoredox/copper catalysis. Based on the results of a deuteration experiment and the competition reaction between cyclopropanation and allenation, the mechanism based on a photoredox-neutral-catalysed radical-polar crossover process has been proposed. Synthetic applications of allenes have also been demonstrated.

Synthesis, biological evaluation, quantitative-SAR and docking studies of novel chalcone derivatives as antibacterial and antioxidant agents

In the present study, a series of chalcone derivatives including 17 new compounds were synthesised; their antibacterial activities against eleven bacteria, and their free radical-scavenging activities using DPPH were evaluated. All compounds showed significant antibacterial activities against both Grampositive and Gram-negative bacteria. In particular, compound IIIf strongly inhibited Staphylococcus aureus (JMC 2151) and Enterococcus faecalis (CARS 2011-012) with MIC values of 6.25 μg mL-1 and 12.5 μg mL-1, respectively, which are comparable to that of the standard antibiotic, nalidixic acid. Compound IIIg also inhibited S. aureus with a MIC value similar to that of nalidixic acid (6.25 μg mL-1). Furthermore, like nalidixic acid (MIC value of 25 μg mL-1), compounds IIIa, IIIc and IIId inhibited Listeria monocytogenes (ATCC 43256) with MIC values of 25 μg mL-1, 12.5 μg mL-1 and 25 μg mL-1, respectively. Quantitative structure-activity relationship (Q-SAR) studies using physicochemical calculations indicated that the antibacterial activities of chalcone derivatives correlated well with predicted physicochemical parameters (logP and PSA). Docking simulation by positioning the most active compound IIIf in the active site of the penicillin-binding protein (PBP-1b) of S. aureus was performed to explore the feasible binding mode. Furthermore, most of the compounds synthesised exhibited significant DPPH radical-scavenging activity, although compounds IIc and IIIc exhibited the greatest antioxidant activity with IC50 values of 1.68 μM and 1.44 μM, respectively, comparable to that of the standard antioxidant, ascorbic acid (1.03 μM).

Electrophilic bromination of alkenes, alkynes, and aromatic amines with iodic acid/potassium bromide under mild conditions

Bromination of alkenes, alkynes, and aromatic amines has efficiently been carried out at room temperature in short reaction times using HIO 3/KBr in CH2Cl2/H2O (1:1) to prepare corresponding brominated compounds in excellent yields.