3893-15-0

Basic information

• Product Name: 2-Propenal, 2-Methyl-3-(4-Methylphenyl)-
• Synonyms: 2-Propenal, 2-Methyl-3-(4-Methylphenyl)-
• CAS NO: 3893-15-0
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160
• Mol File: 3893-15-0.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenal, 2-Methyl-3-(4-Methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 2-Methyl-3-(4-Methylphenyl)-(3893-15-0)
• EPA Substance Registry System: 2-Propenal, 2-Methyl-3-(4-Methylphenyl)-(3893-15-0)

Safety Data

• Hazardous Substances Data: 3893-15-0(Hazardous Substances Data)

Usage

General Description

2-Propenal, 2-Methyl-3-(4-Methylphenyl)- is an organic compound with the chemical formula C10H10O. It is a yellowish liquid with a sharp, fruity odor, commonly known as cinnamaldehyde. This chemical is primarily used as a flavoring agent in the food and beverage industry, providing a cinnamon-like taste and aroma to various products. It is also utilized in the production of perfumes, fragrances, and essential oils due to its pleasant scent. In addition, cinnamaldehyde has shown potential health benefits, including anti-inflammatory and antioxidant properties, which have led to applications in traditional medicine and as a natural preservative in various products. However,

Upstream product

• 78-84-2 isobutyraldehyde 
• 108-88-3 toluene 
• 119346-67-7 ethyl (E)-2-methyl-3-(p-tolyl)acrylate 
• 104-87-0 4-methyl-benzaldehyde 
• 113237-60-8 [(E)-2-Methyl-3-p-tolyl-prop-2-en-(E)-ylidene]-phenyl-amine 
• 154581-92-7 (Z)-2-Trimethylsilanyl-1-trimethylsilanyloxy-propene 
• 123-38-6 propionaldehyde 
• 56138-10-4 (2E)-2-methyl-3-(4-methylphenyl)-2-propen-1-ol 

Downstream Products

• 1228457-57-5 C₁₈H₂₇NOSi 
• 1392325-28-8 ethyl (E)-6-(4-methylphenyl)-2-ethyl-5-methyl-3,4-dioxohex-5-enoate 
• 1392325-19-7 C₂₅H₃₇NO₄Si 
• 105984-60-9 2-methyl-3-p-tolylpropan-1-ol 
• 1589518-73-9 N-(2,6-dimethyl-1H-inden-1-yl)-4-methylbenzenesulfonamide 
• 41496-43-9 2-methyl-3-(4-methylphenyl)propanal 
• 1428319-33-8 (E)-1-cyclohexenyl-2-methyl-3-p-tolylprop-2-en-1-ol 
• 1428319-55-4 C₁₇H₂₀Br₂O 
• 1428319-49-6 C₁₇H₂₀O 

Relevant articles and documents

Asymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co–Catalyzed, Enantioselective Proton-Transfer

We report an enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C?C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis. (Figure presented.).

Dehydrogenative β-Arylation of Saturated Aldehydes Using Transient Directing Groups

An unprecedented cross-dehydrogenative-coupling (CDC) reaction of saturated aldehyde β-C-H with arenes to form cinnamaldehydes via the cleavages of four C-H bonds has been developed. The reaction possesses complete E-stereoselectivity for the C=C double bond. The protocol is featured by atom and step economy, mild reaction conditions, and convenient operation.

A synthetic route to 4-alkyl-α-methylhydrocinnamylaldehydes

The 4-Alkyl-α-methylhydrocinnamylaldehydes (alkyl-isopropyl, isobutyl, methyl) are frequently used fragrances with desired floral (lilac, cyclamen, lily-of-the-valley) scent. These substances are valued for their good stability in basic solution and, therefore, are frequently used in soaps, detergents, or shampoos. These substances are synthesized by a two-step synthesis involving base catalyzed aldol condensation of 4-alkylbenzaldehyde with propanal followed by selective hydrogenation of the C=C bond. In aldol condensation, selectivity is decreased by formation of undesired products of propanal autocondensation 2-methylpent-2-enal. In this work the reaction conditions for homogenous catalyzed aldol condensation of 4-isobutylbenzadehyde with propanal were tested (catalyst type and amount, molar ratio of reactants, solvent type). Reaction conditions giving the best results (92% conversion, 79% selectivity) were adapted to other 4-alkyl-α-methylcinnamylaldehydes preparation with similar results. In the second step—hydrogenation of aldol product different types of catalyst (nickel, cobalt, palladium or Adkins catalyst), and also different solvents, were tested. Hydrogenation conditions leading to the highest yield (72% selectivity at 95% conversion) were adapted to other 4-alkylhydrocinnamyladehydes with similar results.