119346-67-7

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 80-62-6 methacrylic acid methyl ester 
• 145316-15-0 ethyl 2-(hydroxy(p-tolyl)methyl)acrylate 
• 78-38-6 ethylphosphonic acid diethyl ester 
• 105-58-8 Diethyl carbonate 
• 78-40-0 triethyl phosphate 
• 811-49-4 ethyllithium 
• 106046-60-0 3-hydroxy-2-methyl-3-p-tolyl-propionic acid ethyl ester 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 105984-60-9 2-methyl-3-p-tolylpropan-1-ol 
• 56138-10-4 (2E)-2-methyl-3-(4-methylphenyl)-2-propen-1-ol 
• 1228457-57-5 C₁₈H₂₇NOSi 
• 1392325-19-7 C₂₅H₃₇NO₄Si 
• 1392325-28-8 ethyl (E)-6-(4-methylphenyl)-2-ethyl-5-methyl-3,4-dioxohex-5-enoate 
• 3893-15-0 (E)-3-(4-methylphenyl)-2-methylacrylaldehyde 
• 25860-59-7 -2-methyl-3-(4-methylphenyl)prop-2-enoic acid 

Relevant academic research and scientific papers

Arenediazonium salts immobilized in imidazolium ionic liquids as electrophilic partners in the Pd(OAc)2-catalyzed Matsuda-Heck arylation

The utility of arenediazonium salts immobilized in imidazolium-ILs [BMIMPF6 and BMIMBF4] for facile, high yielding, synthesis of olefins via the Pd(OAc)2-catalyzed Matsuda-Heck arylation reaction has been demonstrated. The reaction can also be performed as a two-step process in the IL starting from ArNH2, by sequential in-situ diazotization-arylation. Simple product isolation and the recycling/re-use of the IL are additional advantages of this one-pot method.

Pd-Catalyzed α-Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-Lactams

Pd-catalyzed α-olefinic C-H activation of simple α,β-unsaturated olefins has been developed. 4-imino-β-lactam derivatives were readily synthesized via activation of α-olefinic C-H bonds with excellent cis stereoselectivity. A wide range of heterocycles at the β-position are compatible with this reaction. The product of 4-imino-β-lactam derivatives can be readily converted to 2-aminoquinoline which exists extensively in pharmaceutical drugs and natural products.

Synthesis of trisubstituted alkenes by reductive dehydroxylation of Baylis-Hillman adducts using polymethylhydrosiloxane (PMHS) and catalytic B(C6F5)3

B(C6F5)3 as a catalyst and polymethylhydrosiloxane as a hydride source have been employed for the reductive dehydroxylation of Baylis-Hillman adducts wherein the hydride adds in an SN2′ manner onto the unactivat

PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS

An agent for promoting the proliferation or differentiation of a stem cell and/or neural progenitor cell, comprising a compound represented by Formula: wherein each of R1 and R2 is H, a hydrocarbon group or a heterocyclic group, or taken together with the adjacent carbon atom to form a ring, R3 is H, a hydrocarbon group or a heterocyclic group, W is a group represented by Formula: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R4 is an acyl group having an aliphatic hydrocarbon group, which is substituted by an aromatic group and may have a further substitutent, or aromatic group, R5 is H, C1-6 alkyl or acyl, R4c is an aromatic group, an aliphatic hydrocarbon group or acyl, and X is O or S; Y is O, S or NH, Ring C is an optionally substituted benzene ring, or a salt or prodrug thereof is provided.

Benzofuran derivatives, their production and use

Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.

α-LITHIOALKYLPHOSPHONATES AS FUNCTIONAL GROUP CARRIERS. AN IN SITU ACRYLIC ESTER SYNTHESIS

Condensation of α-lithioalkylphosphonates with diethylcarbonate in the presence of LDA generates carbethoxyalkylphosphonate anions which upon treatment at room temperature with aldehydes constitutes an in situ acrylic ester synthesis.