38939-83-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Acetoxypropionylchloride is used as a key intermediate for the synthesis of various pharmaceuticals. Its ability to acylate alcohols and amines makes it a valuable component in the production of drugs with specific therapeutic properties.
Used in Dye Industry:
In the dye industry, 2-Acetoxypropionylchloride serves as an intermediate in the production of dyes. Its reactivity allows for the creation of a range of colored compounds used in various applications, including textiles and printing inks.
Used in Agricultural Chemicals:
2-Acetoxypropionylchloride is utilized as an intermediate in the synthesis of agricultural chemicals. Its role in creating specific chemical structures contributes to the development of effective pesticides and other agrochemicals.
Used as a Reagent in Organic Synthesis:
2-Acetoxypropionylchloride is used as a reagent in organic synthesis, particularly for the acylation of alcohols and amines. This reaction is crucial for the formation of esters and amides, which are essential building blocks in the creation of complex organic molecules.
Safety Precautions:
As a hazardous substance, 2-Acetoxypropionylchloride requires careful handling to prevent severe irritation to the skin, eyes, and respiratory system. Proper safety measures, including the use of personal protective equipment and handling in well-ventilated areas, should be strictly followed to minimize health risks.

InChI:InChI=1/C5H7ClO3/c1-3(5(6)8)9-4(2)7/h3H,1-2H3

Upstream product

• 535-17-1 (L)-O-Acetyllactic acid 
• 535-17-1 2-acetoxypropionic acid 

Downstream Products

• 6283-90-5 2-acetoxy-propionic acid octyl ester 
• 15657-95-1 O-acetyl-lactic acid amide 
• 6288-19-3 2-acetoxy-propionic acid dibutylamide 
• 100143-12-2 N-(2-acetoxy-propionyl)-anthranilonitrile 
• 51009-58-6 Acetic acid 1-{1-[1-(2-acetoxy-propionylperoxy)-cyclohexylperoxy]-cyclohexylperoxycarbonyl}-ethyl ester 
• 22198-55-6 1-((phenylthio)carbonyl)ethyl acetate 
• 38848-22-5 2-acetoxy-1-(5,8,9,10-tetrahydro-6H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-11-yl)-propan-1-one 
• 82071-51-0 2-(2-Acetoxypropionyl)cyclohexanone 
• 142671-63-4 3,4,4-trimethyl-2-oxothietan-3-yl acetate 
• 273404-63-0 3-{bis[(S)-2-acetoxypropanoyl]amino}-2-diphenylmethylquinazolin-4(3H)-one 
• 19347-08-1 acetic acid 1-methyl-2-oxo-2-phenyl-ethyl ester 

Relevant academic research and scientific papers

Selective Sensing of Fe3+ and Al3+ Ions and Detection of 2,4,6-Trinitrophenol by a Water-Stable Terbium-Based Metal-Organic Framework

A water-stable luminescent terbium-based metal-organic framework (MOF), {[Tb(L1)1.5(H2O)]·3 H2O}n (Tb-MOF), with rod-shaped secondary building units (SBUs) and honeycomb-type tubular channels has been synthesized and structurally characterized by single-crystal X-ray diffraction. The high green emission intensity and the microporous nature of the Tb-MOF indicate that it can potentially be used as a luminescent sensor. In this work, we show that Tb-MOF can selectively sense Fe3+ and Al3+ ions from mixed metal ions in water through different detection mechanisms. In addition, it also exhibits high sensitivity for 2,4,6-trinitrophenol (TNP) in the presence of other nitro aromatic compounds in aqueous solution by luminescence quenching experiments.

AMINOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (I) where A, B, R1, X1, X2, and W are described herein.

CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I); where A1, A2, G, R1, R2, R3, R4, and W are described herein.

Novel bi-cyclic or tri-cyclic heterocyclic compound

The present invention provides novel bi-cyclic or tri-cyclic compound represented by formula (I) or pharmaceutical acceptable salt thereof, [wherein, ring A is an aromatic group which may be substituted, one of X1 and X2 is a carbon atom, and another is a nitrogen atom, X3 is a nitrogen atom or CR2, X4 is a nitrogen atom or CR3, X5 is a sulfur atom or -CH=CH-, Z1 is an oxygen atom, -C(R6)(R7)-, -NH-, -C(R6)(R7)-NH-, -NH-C(R6)(R7)-, -C(R6)(R7)-O-, -O-C(R6)(R7)- or a single bone, one of Z2 and Z3 is CH and another one is a nitrogen atom, or both are nitrogen atoms, the other symbols are same as those defined in the specification.]

PARASITICIDAL COMPOUNDS, METHODS, AND FORMULATIONS

Provided are dihydroisoxazole compounds useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. Also provided are compounds and processes useful for making the dihydroisoxazole compounds.

PARASITICIDAL DIHYDROISOXAZOLE COMPOUNDS

Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. Also provided are compounds and processes useful for making the dihydroisoxazole compounds.

Substituted piperazines as metabotropic glutamate receptor antagonists

The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.

Synthesis of chrysogine, a metabolite of Penicillium chrysogenum and some related 2-substituted 4-(3H)-quinazolinones

Syntheses of both enantiomers of chrysogine, 2-(α-hydroxyethyl)-4(3H)-quinazolinone, 1 from 2-ammobenzamide are reported. Thus reaction of 2-aminobenzamide and optically active α-acetoxypropionyl chloride gave 9, which upon saponification and cyclization induced by aqueous sodium carbonate at room temperature gave chrysogine. The enantiomeric purity of 1 was determined by NMR. Inversion of (-)-(S)-1, using the Mitsunobo reaction, gave (+)-(R)-1. Reduction of 2-acetyl-4(3H)-qumazolinone 2 with baker's yeast gave the S-enantiomer of 1. The cyclization method used could be extended and a number of 2-(a-hydroxy)alkyl-4-(3H)-quinazolinones are also reported.

Un nouveau mode de cyclisation de ceto-ylures: synthese de -furannones-3 fonctionelles

Condensation of Ph3P=CH-COOEt on esters of the lactic acid chloride ClCOCH(Me)COOR' leads, according to a new cyclization process, to functional 3-furanones which undergo slow oxidation in the presence of air, giving the corresponding hydroxyfuranones.One of the latter has been chosen as a model for a complete 13C NMR study.

TOTAL SYNTHESIS OF (+)-PEDERINE. A SIMPLE SYNTHETIC METHOD FOR N-(1-METHOXYALKYL)AMIDES

A mild one-pot method for the synthesis of acyclic N-(1-methoxyalkyl)amides starting from carboxylic acids and methyl imidates had been developed and applied to the total synthesis of the insect poison pederine 1.