3904-18-5

Basic information

• Product Name: 2,4,5-TRIMETHOXYLPRORIOPHENONE
• Synonyms: 2,4,5-TRIMETHOXYLPRORIOPHENONE;1-(2,4,5-TRIMETHOXYPHENYL)PROPAN-1-ONE;2,4,5-TRIMETHOXYLPROPRIOPHENONE
• CAS NO: 3904-18-5
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.25
• Mol File: 3904-18-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 108.5-109.5 °C
• Boiling Point: 342.4°C at 760 mmHg
• Flash Point: 150.5°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 7.54E-05mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: 2,4,5-TRIMETHOXYLPRORIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIMETHOXYLPRORIOPHENONE(3904-18-5)
• EPA Substance Registry System: 2,4,5-TRIMETHOXYLPRORIOPHENONE(3904-18-5)

Safety Data

• Hazardous Substances Data: 3904-18-5(Hazardous Substances Data)

Usage

Preparation

Preparation from 1,2,4-trimethoxybenzene by reaction, with propionic anhydride catalyzed either by iodine or aluminium chloride; with propionyl chloride in the presence of aluminium chloride in methylene chloride at 10° for 1 h (80%)or in carbon disulfide (67%).

InChI:InChI=1/C12H16O4/c1-5-9(13)8-6-11(15-3)12(16-4)7-10(8)14-2/h6-7H,5H2,1-4H3

Upstream product

• 135-77-3 1,2,4-trimethoxy-benzene 
• 79-03-8 propionyl chloride 
• 22973-79-1 2-(2,4,5-trimethoxyphenyl)acetaldehyde 
• 29652-82-2 1-(2,4,5-Trimethoxyphenyl)propan-1-ol 
• 6906-65-6 1-propyl-2,4,5-trimethoxybenzene 
• 494-40-6 asarone 
• 613-03-6 1,2,4-triacetoxybenzene 
• 802294-64-0 propionic acid 
• 1214-72-8 1-(1,2-dibromo-propyl)-2,4,5-trimethoxy-benzene 
• 77-78-1 dimethyl sulfate 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 6906-65-6 1-propyl-2,4,5-trimethoxybenzene 
• 29652-82-2 1-(2,4,5-Trimethoxyphenyl)propan-1-ol 
• 802294-64-0 propionic acid 
• 1229005-35-9 (2R)-1-(2,4,5-trimethoxyphenyl)propan-2-ol-1-one 

Relevant articles and documents

Iron-Catalyzed Wacker-type Oxidation of Olefins at Room Temperature with 1,3-Diketones or Neocuproine as Ligands**

Herein, we describe a convenient and general method for the oxidation of olefins to ketones using either tris(dibenzoylmethanato)iron(III) [Fe(dbm)3] or a combination of iron(II) chloride and neocuproine (2,9-dimethyl-1,10-phenanthroline) as catalysts and phenylsilane (PhSiH3) as additive. All reactions proceed efficiently at room temperature using air as sole oxidant. This transformation has been applied to a variety of substrates, is operationally simple, proceeds under mild reaction conditions, and shows a high functional-group tolerance. The ketones are formed smoothly in up to 97 % yield and with 100 % regioselectivity, while the corresponding alcohols were observed as by-products. Labeling experiments showed that an incorporated hydrogen atom originates from the phenylsilane. The oxygen atom of the ketone as well as of the alcohol derives from the ambient atmosphere.

Green and simple preparation process of alpha-asarone

The invention relates to the technical field of medicine, in particular to a green and simple preparation process of alpha-asarone. 1,2,4-trimethoxybenzene is adopted as a raw material, and three steps, namely, an acylation reaction, a reduction reaction and a dehydration reaction are included. Through the preparation process of alpha-asarone, the total yield can reach 62.3% or above, all organicsolvents can be recycled repeatedly, and the process has the advantages of low cost, small pollution, safe and convenient operation, high yield and the like.

Short Enantioselective Total Synthesis of Tatanan A and 3-epi-Tatanan A Using Assembly-Line Synthesis

Short and highly stereoselective total syntheses of the sesquilignan natural product tatanan A and its C3 epimer are described. An assembly-line synthesis approach, using iterative lithiation–borylation reactions, was applied to install the three contiguo