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1,2,4-Trimethoxy-5-propenylbenzene, commonly known as apiole, is a naturally occurring organic compound that belongs to the phenylpropanoid class. It is found in various plants such as parsley and dill and is known for its wide range of biological activities. Apiole has been traditionally used as a folk remedy for various ailments due to its diuretic, stimulant, and emmenagogue properties. Moreover, it has been studied for its potential therapeutic benefits, including antibacterial and antifungal properties.

494-40-6

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494-40-6 Usage

Uses

Used in Traditional Medicine:
1,2,4-Trimethoxy-5-propenylbenzene is used as a traditional folk remedy for various ailments, such as promoting diuresis, stimulating the body, and acting as an emmenagogue to regulate menstrual flow.
Used in Antibacterial Applications:
1,2,4-Trimethoxy-5-propenylbenzene is used as an antibacterial agent, exhibiting potential to inhibit the growth of certain bacteria, which can be beneficial in treating bacterial infections.
Used in Antifungal Applications:
1,2,4-Trimethoxy-5-propenylbenzene is used as an antifungal agent, showing the ability to combat fungal infections by inhibiting the growth of fungi.
Used in Pharmaceutical Industry:
1,2,4-Trimethoxy-5-propenylbenzene is used as a potential therapeutic agent in the pharmaceutical industry due to its wide range of biological activities and potential health benefits.
Used in Food Industry:
1,2,4-Trimethoxy-5-propenylbenzene, being a naturally occurring compound in plants like parsley and dill, may be used in the food industry for its flavoring properties and potential health benefits when consumed as part of a diet rich in these plants.

Check Digit Verification of cas no

The CAS Registry Mumber 494-40-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 494-40:
(5*4)+(4*9)+(3*4)+(2*4)+(1*0)=76
76 % 10 = 6
So 494-40-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H24O3/c1-7-16(19-4)13-10-11-14(17(8-2)20-5)15(12-13)18(9-3)21-6/h7-12H,1-6H3

494-40-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4,5-Trimethoxy-1-propenylbenzene

1.2 Other means of identification

Product number -
Other names Benzene, 1,2,4-trimethoxy-5-(1-propenyl)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:494-40-6 SDS

494-40-6Relevant academic research and scientific papers

Photoacid-Enabled Synthesis of Indanes via Formal [3 + 2] Cycloaddition of Benzyl Alcohols with Olefins

Yang, Biao,Dong, Kui,Li, Xiang-Sheng,Wu, Li-Zhu,Liu, Qiang

supporting information, p. 2040 - 2044 (2022/03/17)

An environmentally friendly and highly diastereoselective method for synthesizing indanes has been developed via a metastable-state photoacid system containing catalytic protonated merocyanine (MEH). Under visible-light irradiation, MEH yields a metastable spiro structure and liberated protons, which facilitates the formation of carbocations from benzyl alcohols, thus delivering diverse molecules in the presence of various nucleophiles. Mainly, a variety of indanes could be easily obtained from benzyl alcohols and olefins, and water is the only byproduct.

Larvicidal and structure-activity studies of natural phenylpropanoids and their semisynthetic derivatives against the tobacco armyworm Spodoptera litura (Fab.) (Lepidoptera: Noctuidae)

Bhardwaj, Anu,Tewary, Dhananjay Kumar,Kumar, Rakesh,Kumar, Vinod,Sinha, Arun Kumar,Shanker, Adarsh

experimental part, p. 168 - 177 (2010/04/29)

The larvicidal activity of 18 phenylpropanoids, 1-18, including phenylpropenoate, phenylpropenal, phenylpropene, and their semisynthetic analogues, were evaluated against the tobacco armyworm, Spodoptera litura (FAB.), to identify promising structures with insecticidal activity. Amongst various phenylpropanoids, isosafrole, a phenylpropene, showed the best activity, with an LC50 value of 0.6 μg/leaf cm2, followed by its hydrogenated derivative dihydrosafrole (LC50=2.7 μg/leaf cm 2). The overall larvicidal activity of various phenylpropene derivatives was observed in the following order: isosafrole (6) >dihydrosafrole (16)>safrole (12)>anethole (4)>methyl eugenol (11)>eugenol (13)>β-asarone (8)>dihydroasarone (18)>dihydroanethole (15). Dihydrosafrole might be a promising compound, although presenting a lower larvicidal activity than isosafrole, because of its better stability and resistance to oxidative degradation (due to the removal of the extremely reactive olefinic bond) in comparison to isosafrole. Such structure-activity relationship studies promote the identification of lead structures from natural sources for the development of larvicidal products against S. litura and related insect pests.

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