39077-58-2

Usage

Also Known As

2-cyano-3-(2-pyridinyl)-2-propene

Chemical Class

Aryl nitriles

Chemical Structure

Consists of a pyridine ring attached to a propenenitrile moiety

Common Uses

Synthesis of various organic compounds
Found in pharmaceuticals, agrochemicals, and materials science

Investigated Applications

Medicinal chemistry for drug development

Potential Applications

Treatment of various diseases

Variability

Specific uses and properties may vary depending on application and formulation.

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 107-14-2 chloroacetonitrile 
• 793706-87-3 (1,1-dimethylethoxy)diphenylsilylacetonitrile 
• 75-05-8 acetonitrile 
• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 
• 99584-02-8 (E)-3-(pyridin-2-yl)acrylamide 
• 28823-16-7 (2E)-3-(2-pyridinyl)-2-propenal 

Relevant academic research and scientific papers

Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

(E)-3-heteroaromatic propyl-2-enoic acid derivative as well as preparation and application thereof

The invention relates to a (E)-3-heteroaromatic propyl-2-enoic acid derivative, and also relates to a preparation method and pharmaceutical application thereof. The compound is a novel Nrf2 activatorand has the effects of resisting oxidative stress, resisting neuritis and enhancing mitochondrial functions and biogenesis by effectively activating an Nrf2 signal path, so that nerve cells are protected, and the compound can be used for treating neurodegenerative diseases and cerebral apoplexy. In addition, the novel Nrf2 activator can also be used to treat autoimmune diseases, diabetes and nephropathy, and other chronic diseases.

A Catalytic Peterson-like Synthesis of Alkenyl Nitriles

A heterogeneous fluoride catalyst was found to enable the straightforward formation of alkenyl nitriles from the reaction of aldehydes and simple or substituted acetonitriles, in the presence of commercially available silazanes and in solvent-free conditions. The protocol afforded the products in good to excellent yields with selectivity values dependent on the nature of the substrates. It represents an alternative to classic approaches using stoichiometric strong bases, and the catalyst can be easily recovered and reused for consecutive cycles.

Synthesis of pyrido[1,2- a ]indole malonates and amines through aryne annulation

Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]indoles in moderate to good yields.

5, 7-SUBSTITUTED-IMIDAZO [1, 2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES

Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Highly (Z)-selective synthesis of β-monosubstituted α,β-unsaturated cyanides using the peterson reaction

(Chemical Equation Presented) The Peterson reaction between (t-BuO)Ph 2SiCH2CN and various aldehydes furnishes the corresponding β-monosubstituted α,β-unsaturated cyanides with high Z selectivity (Z:E = 92:8 to >98:2).

Synthesis of α,β-unsaturated nitriles from the iodine catalyzed reaction of chloroacetonitrile with aldehydes promoted by tri-n-butylarsine and magnesium

α,β-Unsaturated nitriles were synthesized from the iodine catalyzed reaction of chloro- acetonitrile with aldehydes promoted by tri-n-butylarsine and magnesium.