391-45-7

Basic information

• Product Name: 3-Fluorocarbazole
• Synonyms: 3-Fluorocarbazole;3-Fluoro-9H-carbazole
• CAS NO: 391-45-7
• Molecular Formula: C₁₂H₈FN
• Molecular Weight: 185.1970232
• EINECS: -0
• Mol File: 391-45-7.mol
• Article Data: 21

Chemical Properties

• Melting Point: 210.0 to 214.0 °C
• Boiling Point: 359.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.320±0.06 g/cm3(Predicted)
• PKA: 16.80±0.30(Predicted)
• CAS DataBase Reference: 3-Fluorocarbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluorocarbazole(391-45-7)
• EPA Substance Registry System: 3-Fluorocarbazole(391-45-7)

Safety Data

• Hazardous Substances Data: 391-45-7(Hazardous Substances Data)

Usage

Uses

3-Fluoro-9H-carbazole was studied for its potential as a kinesin spindle protein inhibitor.

Upstream product

• 95-51-2 o-chloroaniline 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 108-94-1 cyclohexanone 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 2367-17-1 6-fluoro-1,2,3,4-tetrahydrocarbazole 
• 61272-76-2 4-fluoro-2-iodoaniline 
• 191171-55-8 2-anilineboronic acid pinacol ester 
• 98-80-6 phenylboronic acid 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 132993-23-8 4-fluorophenyl trifluoromethanesulfonate 
• 62-53-3 aniline 
• 371-41-5 4-Fluorophenol 
• 1717-22-2 2-amino-5-fluorobiphenyl 
• 1140969-90-9 C₁₂H₈FN₃ 

Relevant articles and documents

Fluorine-substituted monocarbazole derivative as well as preparation method and application thereof (by machine translation)

The invention belongs to the field of pharmaceutical chemistry, and relates to a fluorine-substituted monocarbazole derivative which is one or more of compounds represented by formula (I) and formula (II) or a pharmaceutically acceptable soluble salt formed by a compound represented by formula (II). The fluorine-substituted monocarbazole derivatives obtained in the application can be used for preparing DNA methyltransferase inhibitors or histone demethylase inhibitors. The fluorine-substituted monocarbazole derivative has an inhibitory effect on the proliferation of cancer cells and can be used for preparing medicaments for treating and/or preventing cancer. An in-vitro cancer cell proliferation inhibition test shows that the fluorine-substituted monocarbazole compound obtained by the invention shows anti-proliferation activity against human lung cancer cells (A549), human colon cancer cells (HCTCTCT116), human gastric cancer cells (MNK NK NK-45), human liver cancer cells (HepepepG2), RPMI PMI PMI PMI PMI PMI and Karpppp289. (by machine translation)

5,6-Bis(9-(2-decyltetradecyl)-6-fluoro-9H-carbazol-3-yl)naphtho[2,1-b:3,4-b']dithiophene as a Promising Donor Structure for D–A Conjugated Copolymers with a Narrow Bandgap

A new carbazole-containing naphthodithiophene derivative—heteroaromatic compound 5,6- bis[9-(2-decyltetradecyl)-9H-carbazol-3-yl]naphtho[2,1-b:3,4-b']dithiophene (M1)—has been synthesized. The compound will be used by us as a weak donor structural block for fabricating narrow-bandgap D–A conjugated polymers. The composition and structure of M1 have been confirmed by elemental analysis data, IR spectroscopy, and 1H and 13C NMR. The synthesized compound has a low HOMO energy (–5.4 eV), which is favorable for a high open-circuit voltage. Monomer M1 can be used as a promising weak donor moiety in D–A conjugated polymers for solar photovoltaics.

Visible-light-promoted intramolecular C-H amination in aqueous solution: Synthesis of carbazoles

An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as a co-solvent, visible-light rather than various metals is used to facilitate the conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactive natural alkaloids, such as glycoborine, clausine C, clausine L, clausine H and clauszoline K, were synthesized efficiently with nitrogen as a sole byproduct. The reaction could be performed in water, acidic or alkaline buffer solutions, showing its potential for applications in biochemistry.