39144-65-5

Basic information

• Product Name: methyl 2,2-bis(4-fluorophenyl)acetate
• Synonyms: methyl 2,2-bis(4-fluorophenyl)acetate
• CAS NO: 39144-65-5
• Molecular Weight: 262.256
• Mol File: 39144-65-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2,2-bis(4-fluorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,2-bis(4-fluorophenyl)acetate(39144-65-5)
• EPA Substance Registry System: methyl 2,2-bis(4-fluorophenyl)acetate(39144-65-5)

Safety Data

• Hazardous Substances Data: 39144-65-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 361-63-7 2,2-bis(4-fluorophenyl)acetic acid 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 
• 124-38-9 carbon dioxide 
• 339-27-5 difluorophenyl-di-(p-fluorophenyl)methane 
• 74-88-4 methyl iodide 
• 345-92-6 4,4'-Difluorobenzophenone 

Downstream Products

• 1219624-43-7 3,3-bis(4-fluorophenyl)pyrrolidin-2-one 
• 1219624-94-8 3,3-bis(4-fluorophenyl)piperidin-2-one 
• 1219624-44-8 ethyl 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetate 
• 1219624-95-9 ethyl 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetate 
• 1219624-45-9 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid 
• 1219624-96-0 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid 
• 1219624-41-5 1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)pyrrolidin-2-one 
• 1219624-92-6 1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one 
• 1219624-47-1 3,3-bis(4-fluorophenyl)-1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)pyrrolidin-2-one 
• 1219626-01-3 3,3-bis(4-fluorophenyl)-1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)piperidin-2-one 

Relevant articles and documents

Boryl Radical Activation of Benzylic C-OH Bond: Cross-Electrophile Coupling of Free Alcohols and CO2via Photoredox Catalysis

A new strategy for the direct cleavage of the C(sp3)-OH bond has been developed via activation of free alcohols with neutral diphenyl boryl radical generated from sodium tetraphenylborate under mild visible light photoredox conditions. This strategy has been verified by cross-electrophile coupling of free alcohols and carbon dioxide for the synthesis of carboxylic acids. Direct transformation of a range of primary, secondary, and tertiary benzyl alcohols to acids has been achieved. Control experiments and computational studies indicate that activation of alcohols with neutral boryl radical undergoes homolysis of the C(sp3)-OH bond, generating alkyl radicals. After reducing the alkyl radical into carbon anion under photoredox conditions, the following carboxylation with CO2 affords the coupling product.

CYCLIC AMINE COMPOUND

An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of a2C-adrenoceptor and is useful in preventing and treating disorders attributable to a2C-adrenoceptor.The above-described object is solved by the following cyclic amine compound, etc., wherein X is O, S, SO, SO2 or NR2, etc.; R1 is a hydrogen atom, a cyano group, a carboxyl group, a C2-C13 alkoxycarbonyl group, a carbamoyl group, etc.; Ar1 and Ar2 are the same or different and each represent an aryl or heteroaryl group which may be substituted by 1 to 3 substituents and so on; ring B is a benzene ring may be substituted by 1 to 3 substituents and so on; n is an integer from 1 to 10; and p and q are the same or different and each represent an integer of 1 or 2.