39149-13-8

Usage

Uses

Used in Pharmaceutical Industry:
4-acetaminophenoxyacetic acid is used as an intermediate for the synthesis of organic compounds, contributing to the development of pharmaceutical products.
Used in Pain Relief Applications:
4-acetaminophenoxyacetic acid is used as an analgesic agent for the treatment of pain, leveraging the pain-relieving properties of acetaminophen.
Used in Anti-Inflammatory Applications:
4-acetaminophenoxyacetic acid is used as an anti-inflammatory agent, harnessing the anti-inflammatory properties of acetic acid to address inflammation.
Used in Central Nervous System Drug Development:
4-acetaminophenoxyacetic acid is used as a key component in the production of drugs that target specific receptors in the central nervous system, potentially offering novel therapeutic approaches for various neurological conditions.

InChI:InChI=1/C10H11NO4/c1-7(12)11-8-2-4-9(5-3-8)15-6-10(13)14/h2-5H,6H2,1H3,(H,11,12)(H,13,14)

Upstream product

• 2298-36-4 4-aminophenoxyacetic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 103-90-2 4-acetaminophenol 
• 67202-81-7 ethyl 2-[4-(acetylamino)phenoxy]acetate 
• 79-11-8 chloroacetic acid 
• 1798-11-4 4-nitrophenoxyacetic acid 

Downstream Products

• 99072-52-3 (4-acetylamino-2-nitro-phenoxy)-acetic acid 
• 861797-43-5 (4-acetylamino-3-nitro-phenoxy)-acetic acid 
• 13730-70-6 (4-acetylamino-3,5-dinitro-phenoxy)-acetic acid 
• 1616074-87-3 2-(4-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide 
• 29289-37-0 (4-acetylamino-phenoxy)-acetic acid p-phenetidide 
• 2298-36-4 4-aminophenoxyacetic acid 
• 861613-09-4 (4-amino-3,5-dinitro-phenoxy)-acetic acid 
• 59820-55-2 2-(3-arnino-4-nitrophenoxy)acetic acid 
• 69447-81-0 (4-hydrazino-phenoxy)-acetic acid 
• 42288-38-0 (3,5-dinitro-phenoxy)-acetic acid 
• 329-71-5 2,5-dinitrophenol 
• 101284-10-0 (4-acetylamino-phenoxy)-acetic acid phenyl ester 

Relevant academic research and scientific papers

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols

Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.

Boron trifluoride-methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity

A boron trifluoride-methanol complex demonstrated remarkable deprotection selectivity against commonly used amino-protecting groups in the deacetylation of acetanilides and high sensitivity to the steric hindrance of substrates. The scope and limitations of the reaction were explored.

Finding new elicitors that induce resistance in rice to the white-backed planthopper Sogatella furcifera

Herein we report a new way to identify chemical elicitors that induce resistance in rice to herbivores. Using this method, by quantifying the induction of chemicals for GUS activity in a specific screening system that we established previously, 5 candidate elicitors were selected from the 29 designed and synthesized phenoxyalkanoic acid derivatives. Bioassays confirmed that these candidate elicitors could induce plant defense and then repel feeding of white-backed planthopper Sogatella furcifera.

PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5- mediated disorders are also described.

Functionalized drugs and polymers derived therefrom

Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone moiety), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO—, where y is 2-4 or 6-24 and —(CH2CH2O)zCH2COO—, where z is 2-24; each Y is independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester moiety), —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety), —CO(CH2)mO—, where m is 2-4 or 6-24 and —COCH2O(CH2CH2O)n— where n is between 2-24; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.

Substituted piperidine compounds useful as modulators of chemokine receptor activity

The invention provides compounds of formula (I) wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions