39150-45-3

Basic information

• Product Name: 3,5-DIBROMOSULFANILAMIDE
• Synonyms: 2,6-dibromosulfanilamide;3,5-DIBROMOSULFANILAMIDE: TECH., 80%;3,5-DIBROMOSULPHANILAMIDE 80%;3,5-DIBROMOSULFANILAMIDE 97+%;3,5-Dibromo-4-aminobenzenesulfonamide;Benzenesulfonamide, 4-amino-3,5-dibromo-;dibromosulfanilamide;3,5-DIBROMOSULPHANILAMIDE
• CAS NO: 39150-45-3
• Molecular Formula: C₆H₆Br₂N₂O₂S
• Molecular Weight: 330
• EINECS: 254-321-8
• Mol File: 39150-45-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 235-237°C
• Boiling Point: 458.2°Cat760mmHg
• Flash Point: 230.9°C
• Appearance: /
• Density: 2.156g/cm³
• Vapor Pressure: 1.4E-08mmHg at 25°C
• Refractive Index: 1.686
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.57±0.60(Predicted)
• CAS DataBase Reference: 3,5-DIBROMOSULFANILAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIBROMOSULFANILAMIDE(39150-45-3)
• EPA Substance Registry System: 3,5-DIBROMOSULFANILAMIDE(39150-45-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 39150-45-3(Hazardous Substances Data)

Usage

General Description

3,5-Dibromosulfanilamide is a chemical compound with the formula C6H5Br2NO2S. It is used as a disinfectant and antimicrobial agent in various applications, including as an additive in personal care and hygiene products. 3,5-DIBROMOSULFANILAMIDE is known for its broad-spectrum antimicrobial activity against a variety of microorganisms, including bacteria and fungi. It functions by disrupting the cell walls and membranes of these microorganisms, effectively killing them. Its effectiveness and relatively low toxicity make it a valuable compound in the development of new antimicrobial agents for various applications, from medical and pharmaceutical to personal care and consumer products.

InChI:InChI=1/C6H6Br2N2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12)

Upstream product

• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 63-74-1 sulfanilamide 
• 614-76-6 N-acetyl-2-bromoaniline 
• 88963-75-1 4-acetamido-3-bromobenzene-1-sulfonyl chloride 
• 615-36-1 2-bromoaniline 
• 53297-69-1 4-amino-3-bromo-benzenesulfonamide 
• 547742-79-0 4-acetylamino-3-bromo-benzenesulfonic acid amide 

Downstream Products

• 608-30-0 2,6-dibromoaniline 
• 147-82-0 2,4,6-tribromoaniline 
• 39234-98-5 4-amino-3,5-dibromobenzenesulfonyl chloride 
• 39234-97-4 4-amino-3,5-dibromo-N-isopropylbenzenesulfonamide 
• 608-21-9 1,2,3-tribromobenzene 
• 15018-96-9 acetyl-(4-amino-3,5-dibromo-benzenesulfonyl)-amine 
• 1613692-28-6 C₄₅H₄₃ClN₂O₂Pd 
• 1613692-27-5 C₅₁H₅₅ClN₂Pd 
• 1613692-30-0 C₄₄H₄₀N₂O₂ 
• 1613692-29-7 C₅₀H₅₂N₂ 

Relevant articles and documents

Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors

Thiourea derivatives have drawn much attention for their latent capacities of biological activities. In this study, we designed acylthiourea compounds as polo-like kinase 1 (Plk1) polo-box domain (PBD) inhibitors. A series of acylthiourea derivatives without pan assay interference structure (PAINS) were synthesized. Four compounds with halogen substituents exhibited binding affinities to Plk1 PBD in low micromole range. The most potent compound (3v) showed selectivity over other subtypes of Plk PBDs and inhibited the kinase activity of full-length Plk1.

An instant and facile bromination of industrially-important aromatic compounds in water using recyclable CaBr2-Br2 system

Various industrially-important brominated intermediates have been instantly synthesized using aq. CaBr2-Br2 system as an efficient and recyclable brominating reagent under aqueous conditions at room temperature without the need for metal catalysts or acidic additives. Structurally-diverse phenol and aniline derivatives with strong electron-withdrawing groups such as carboxylic, nitro and formyl show remarkable reactivity to the brominating reagent and brominated in 92-98% yield with high purity (>99%) in a very short reaction time. Organic solvent-free conditions, a feature of the green chemistry, were successively used not only for the reactions but also for the isolation of products at the end of the reaction. The recycling of HBr by its neutralization, thereby generating additional amounts of industrially-important CaBr2 has been designed and developed. The brominating reagent has been recycled and regenerated, and the process was repeated up to 4 cycles after the fresh batch using the regenerated brominating reagent having almost identical selectivity and isolated yields, which seems to be the most promising methodology from the viewpoint of the green approach to organic synthesis.

Magnetic susceptibilities of organic compounds: Part V - Influence of substituents on diamagnetic susceptibilities of disubstituted and trisubstituted benzenes

The magnetic susceptibilities of a number of triads of isomeric disubstituted benzenes have been determined, choosing the compounds in such a way that the substituents are present in the following combinations: (i) two electron-releasing substituents, (ii) a halogeno and an electron-releasing substituent, (iii) a halogeno and an electron-attracting substituent, and (iv) two halogeno substituents.The data show that for types (i), (ii) and (iv), the ortho isomers have the highest magnetic susceptibilities, the susceptibilities decreasing in the order: ortho > meta > para; for type (iii), the meta-isomers have the highest susceptibilities, the susceptibilities decreasing in the order: meta > para > ortho.The diamagnetic susceptibilities of some isomeric trisubstituted benzenes have also been determined and the data reveal that the susceptibility is the highest where the crowding of substituents is the highest (1,2,3-isomer) and lowest where the substituents are staggered and least crowded (1,3,5-isomer).Another observation made in the case of trisubstituted benzene is the applicability of a principle of additivity of their diamagnetic susceptibilities.