391624-46-7Relevant articles and documents
Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy
Boeijen,Van Ameijde,Liskamp
, p. 8454 - 8462 (2001)
A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).
Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides
Pícha, Jan,Fabre, Benjamin,Budě?ínsky, Milo?,Hajduch, Jan,Abdellaoui, Mehdi,Jirá?ek, Ji?í
supporting information, p. 5180 - 5192 (2018/08/01)
Multi-orthogonal scaffolds can be useful for the attachment of several different compounds to the same central skeleton. Such compounds can find applications in the development of protein mimics because of their potential to mimic several distant epitopes
Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines
Jong, Thingsoon,Bradley, Mark
supporting information, p. 422 - 425 (2015/03/03)
A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.
