39178-30-8

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 25355-40-2 3,4-dihydro-1-methyl-2-(methylthio)-5H-pyrrolium iodide 
• 123-54-6 acetylacetone 
• 67-64-1 acetone 
• 39650-82-3 2,2-dimethoxy-1-methylpyrrolidine 
• 39178-24-0 1-Methyl-5-(2-oxo-propylsulfanyl)-3,4-dihydro-2H-pyrrolium; bromide 
• 78167-69-8 tert-Butyl 2-(1-methyl-2-pyrrolidinylidene)-3-oxobutanoate 
• 542-05-2 acetonedicarboxylic acid 
• 10441-57-3 1-methyl-pyrrolidine-2-thione 

Relevant academic research and scientific papers

THE APPLICATION OF THE SULPHIDE CONTRACTION TO THE SYNTHESIS OF SOME SIMPLE PYRROLIDINE ALKALOIDS

The alkaloids (+/-)-hygrine, (+/-)-dehydrodarlinine, (+/-)-dehydrodarlingianine, and (+/-)-N-methylruspolinone have been synthesised by selective reduction of vinylogous amides formed by sulphide contraction of the salts prepared by reaction of N-methyl-2

Lactam Acetals: Part VI - A Novel Synthesis of 4-Substituted 6,7-Dicarbomethoxy-2,3-dihydro-1-methylindoles

Reaction of 2-(α-alkanoyl/aroyl)methylene-1-methylpyrrolidines (2-5) with dimethyl acetylenedicarboxylate furnishes 4-alkyl/aryl-6,7-dicarbomethoxy-2,3-dihydro-1-methylindoles (6-9).Since 2-5 are readily accessible via condensation of 2,2-dimethoxy-1-methylpyrrolidine (1) with appropriate alkyl or aryl ketones, this transformation constitutes a facile synthesis of polysubstituted indoles.

Methods for Converting N-Alkyl Lactams to Vinylogous Urethanes and Vinylogous Amides via (Methylthio)alkylideniminium Salts

Treatment of enolizable (methylthio)alkylideniminium salts with active methylene compounds under basic conditions gives Knoevenagel-type adducts in excellent yields.Attempts to convert several of these adducts to vinylogous urethanes and vinylogous amides met with varied success.One-pot preparations of vinylogous urethanes and vinylogous amides from (methylthio)alkylideniminium salts and selected active methylene compounds are also described.