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High quality (S)-Methyl Oxazaborolidine supplier in China
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(S)-2-methyl-CBS-oxazaborolidine
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(S)-2-Methyl-CBS-oxazaborolidine
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USD $ 1.0-1.0 / Gram 10 Gram 10 Kilogram/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
(S)-Methyl oxazaborolidine
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(S)-2-Methyl-CBS-oxazaborolidine
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USD $ 2.0-2.0 / Kilogram 1 Kilogram 1-10 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole / LIDE PHARMA- Factory supply / Best price
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1Mcas112022-81-8(S)-Methyloxazaborolidinewithfactoryprice
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USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 2 Metric Ton/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier
(S)-2-methyl-CBS-oxazaborolidine 112022-81-8
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112022-81-8 Usage

Chemical Properties

Colorless to yellow liquid

Reaction

Convenient catalyst for the enantioselective borane reduction of ketones at ambient temperatures. Asymmetric synthesis of α-chiral hydroxyalkylphosphines via a catalytic, enantioselective reduction of acylphosphines. Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: Stereospecific formation of diarylalkanes and triarylmethanes. Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS.

Uses

suzuki reaction
InChI:InChI=1/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m0/s1

112022-81-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (D2131)  (S)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine  >98.0%(T) 112022-81-8 1g 590.00CNY Detail
TCI America (D2131)  (S)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine  >98.0%(T) 112022-81-8 5g 2,370.00CNY Detail
Alfa Aesar (L14583)  (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene    112022-81-8 1ml 347.0CNY Detail
Alfa Aesar (L14583)  (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene    112022-81-8 5ml 754.0CNY Detail
Alfa Aesar (L14583)  (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene    112022-81-8 25ml 2417.0CNY Detail
Alfa Aesar (L09219)  (S)-2-Methyl-CBS-oxazaborolidine monohydrate, 94%    112022-81-8 250mg 732.0CNY Detail
Alfa Aesar (L09219)  (S)-2-Methyl-CBS-oxazaborolidine monohydrate, 94%    112022-81-8 1g 2195.0CNY Detail
Aldrich (649309)  (S)-(−)-2-Methyl-CBS-oxazaborolidine  ≥95% 112022-81-8 649309-1G 574.47CNY Detail
Aldrich (649309)  (S)-(−)-2-Methyl-CBS-oxazaborolidine  ≥95% 112022-81-8 649309-10G 2,851.29CNY Detail
Aldrich (674648)  (S)-(−)-2-Methyl-CBS-oxazaborolidinesolution  1 M in THF 112022-81-8 674648-5ML 1,652.04CNY Detail
Aldrich (674648)  (S)-(−)-2-Methyl-CBS-oxazaborolidinesolution  1 M in THF 112022-81-8 674648-25ML 5,570.37CNY Detail
Aldrich (457701)  (S)-(−)-2-Methyl-CBS-oxazaborolidinesolution  1 M in toluene 112022-81-8 457701-5ML 787.41CNY Detail

112022-81-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

1.2 Other means of identification

Product number -
Other names (S)-5,5-Diphenyl-2-Methyl-3,4-propano-1,3,2-oxazaborolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112022-81-8 SDS

112022-81-8Synthetic route

methylbis(diisopropylamino)borane
151293-60-6

methylbis(diisopropylamino)borane

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In tetrahydrofuran; toluene reflux for 30 min; solvents are removed;89%
methylboronic acid

methylboronic acid

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In toluene byproducts: H2O; refluxing of pyrrolidine deriv. and methylboronic acid in toluene for 3 h; evapn. of solvent in vac.;86%
With 4 A molecular sieve In toluene byproducts: H2O; react. of pyrrolidine deriv. and methylboronic acid in toluene at 23°C in presence of molecular sieves within 1,5 h; evapn. of solvent in vac.;86%
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In n-heptane at 40℃; Solvent; Temperature; Inert atmosphere; Reflux; Large scale;83%
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In toluene for 3h; Heating;
With 4 A molecular sieve In toluene for 15h; Heating;
In toluene for 14h; Cyclization; Heating;
Trimethylboroxine
823-96-1

Trimethylboroxine

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In toluene at 20℃; for 0.6h;
In toluene
In toluene at 20 - 155℃;
C22H30BNO2

C22H30BNO2

methyldi-n-butoxyborane
86595-28-0

methyldi-n-butoxyborane

A

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

B

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
In toluene for 4h; Heating / reflux;
6-phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one
149915-80-0

6-phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

(R)-6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-ol
895534-20-0

(R)-6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-ol

Conditions
ConditionsYield
Stage #1: 6-phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole With borane N,N-diethylaniline complex In toluene at 30 - 32℃; for 3h;
Stage #2: With hydrogenchloride; methanol; water In toluene for 0.666667h;
98%
(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

2,2,2-trifluoro-1-(1,1'-biphenyl-2-yl)ethanone
302912-29-4

2,2,2-trifluoro-1-(1,1'-biphenyl-2-yl)ethanone

1-([1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethan-1-ol
945978-45-0

1-([1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethan-1-ol

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; toluene96%
With hydrogenchloride In tetrahydrofuran; toluene96%
dimethyl sulfide borane
13292-87-0

dimethyl sulfide borane

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

(3aS)-1-methyl-3, 3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole borane complex

(3aS)-1-methyl-3, 3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole borane complex

Conditions
ConditionsYield
In toluene vac. transferring of toluene onto (S)-2-methyl-CBS-oxazaborolidine; addn. of BH3*SMe2 by syringe at -78°C; stirring at room temp. for 2 hand then at -10°C for 5 h; vac. transferring of pentane; pptn., filtration, washing with pentane; removal of volatiles in vac., drying overnight;91%
BH3.S(CH3)2

BH3.S(CH3)2

(S)-oxazaborolidine

(S)-oxazaborolidine

diethyl ether
60-29-7

diethyl ether

2-pentyl-2-cyclopenten-1-one
25564-22-1

2-pentyl-2-cyclopenten-1-one

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

A

(+)-(1R)-2-pentyl-1-cyclopenten-1-ol

(+)-(1R)-2-pentyl-1-cyclopenten-1-ol

B

(R)-2-pentyl-2-cyclopentenol
202530-97-0

(R)-2-pentyl-2-cyclopentenol

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; methanol; tolueneA n/a
B 89%
Sn(C4H9)3(CH3)2C3HO
160539-64-0

Sn(C4H9)3(CH3)2C3HO

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Sn(C4H9)3(CH3)2C3H2(OH)

Sn(C4H9)3(CH3)2C3H2(OH)

Conditions
ConditionsYield
With benzo[1,3,2]dioxaborole In toluene -30°C to -20°C;85%
C20H16O7

C20H16O7

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

C20H18O7

C20H18O7

Conditions
ConditionsYield
Stage #1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole With dimethylsulfide borane complex In tetrahydrofuran; toluene at 0℃; for 0.25h;
Stage #2: C20H16O7 In tetrahydrofuran at -78 - 20℃; for 1h; stereoselective reaction;
85%
(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
With water77%
3-Nitroacetophenone
121-89-1

3-Nitroacetophenone

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

(R)-1-(3-nitrophenyl)ethanol
76116-24-0

(R)-1-(3-nitrophenyl)ethanol

Conditions
ConditionsYield
Stage #1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole With borane Ν,Ν-diethylaniline complex In toluene at 30℃; for 0.333333h; Inert atmosphere;
Stage #2: 3-Nitroacetophenone In toluene at 30℃; for 5.5h;
74%
1-(3-Bromophenyl)ethanone
2142-63-4

1-(3-Bromophenyl)ethanone

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
With dimethyl sulfide borane In tetrahydrofuran; toluene at 30℃; for 7h;54%
borane-THF

borane-THF

3-(2-bromoacetyl)pyridine hydrobromide
17694-68-7

3-(2-bromoacetyl)pyridine hydrobromide

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

(1R)-2-bromo-1-(3-pyridinyl)-1-ethanol
391906-07-3

(1R)-2-bromo-1-(3-pyridinyl)-1-ethanol

Conditions
ConditionsYield
In tetrahydrofuran; methanol34%
In tetrahydrofuran; methanol27%
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran
aqueous potassium carbonate

aqueous potassium carbonate

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

[3-Hydroxy-3-(3-pyridinyl)propyl]carbamic acid, 1,1-dimethylethyl ester
357405-01-7

[3-Hydroxy-3-(3-pyridinyl)propyl]carbamic acid, 1,1-dimethylethyl ester

Conditions
ConditionsYield
With hydrogenchloride; borane In tetrahydrofuran; methanol; toluene928 mg (73%)
(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

4-chloro-1-(4-methylphenyl)butan-1-one
38425-26-2

4-chloro-1-(4-methylphenyl)butan-1-one

R-α-(3-Chloropropyl)-4-methyl-benzenemethanol
357443-51-7

R-α-(3-Chloropropyl)-4-methyl-benzenemethanol

Conditions
ConditionsYield
In tetrahydrofuran; methanol
{1-[4-(6-Methoxy-pyridin-3-yl)-2-oxo-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl}-carbamic Acid Tert-butyl Ester

{1-[4-(6-Methoxy-pyridin-3-yl)-2-oxo-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl}-carbamic Acid Tert-butyl Ester

dimethyl sulfide borane
13292-87-0

dimethyl sulfide borane

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

{1-[2(R)-Hydroxy-4-(6-methoxy-pyridin-3-yl)-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl }-carbamic Acid Tert-butyl Ester

{1-[2(R)-Hydroxy-4-(6-methoxy-pyridin-3-yl)-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl }-carbamic Acid Tert-butyl Ester

Conditions
ConditionsYield
In tetrahydrofuran; methanol; dichloromethane; toluene
{1-[4-(2-methyl-pyrimidin-5-yl)-2-oxo-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl}-carbamic Acid Tert-butyl Ester

{1-[4-(2-methyl-pyrimidin-5-yl)-2-oxo-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl}-carbamic Acid Tert-butyl Ester

dimethyl sulfide borane
13292-87-0

dimethyl sulfide borane

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

{1-[2-Hydroxy-4-(2-methyl-pyrimidin-5-yl)-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl}-carbamic Acid Tert-butyl Ester

{1-[2-Hydroxy-4-(2-methyl-pyrimidin-5-yl)-but-3-enyl]-5(R)-methyl-2-oxo-pyrrolidin-3(S)-yl}-carbamic Acid Tert-butyl Ester

Conditions
ConditionsYield
In tetrahydrofuran; methanol; dichloromethane; toluene
borane-THF

borane-THF

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

(S)-2-bromo-1-(2,4-dichlorophenyl)ethan-1-ol
187164-20-1

(S)-2-bromo-1-(2,4-dichlorophenyl)ethan-1-ol

Conditions
ConditionsYield
In tetrahydrofuran; methanol
(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepine-4,8-dione
191591-86-3

5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepine-4,8-dione

(+)-5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-8-hydroxy-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepin-4-one

(+)-5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-8-hydroxy-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepin-4-one

Conditions
ConditionsYield
In toluene
(E)-(phenylsulfinyl)but-3-en-2-one
33944-98-8

(E)-(phenylsulfinyl)but-3-en-2-one

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

(R,E)-4-phenylthio-3-buten-2-ol

(R,E)-4-phenylthio-3-buten-2-ol

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone
655-32-3

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

2,2,2-trifluoro-1-(4-fluorophenyl)ethanol
17556-41-1, 50562-19-1, 131832-02-5

2,2,2-trifluoro-1-(4-fluorophenyl)ethanol

Conditions
ConditionsYield
With benzo[1,3,2]dioxaborole In dichloromethane at -78℃;n/a
borane
13283-31-3

borane

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In tetrahydrofuran react. of oxazaborolidine deriv. and BH3 in soln.; not isolated;
isopropyl 7-{(4R)-4-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-en-1-yl]-2-oxo-1,3-oxazinan-3-yl}heptanoate
768400-09-5

isopropyl 7-{(4R)-4-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-en-1-yl]-2-oxo-1,3-oxazinan-3-yl}heptanoate

isopropyl 7-[(4R)-4-formyl-2-oxo-1,3-oxazinan-3-yl]heptanoate
768400-08-4

isopropyl 7-[(4R)-4-formyl-2-oxo-1,3-oxazinan-3-yl]heptanoate

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

isopropyl 7-{(4R)-4-[(1E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-yl]-2-oxo-1,3-oxanzinan-3-yl}heptanoate

isopropyl 7-{(4R)-4-[(1E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-yl]-2-oxo-1,3-oxanzinan-3-yl}heptanoate

Conditions
ConditionsYield
Stage #1: isopropyl 7-{(4R)-4-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-en-1-yl]-2-oxo-1,3-oxazinan-3-yl}heptanoate; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole With benzo[1,3,2]dioxaborole In toluene at -78℃; for 1h;
Stage #2: isopropyl 7-[(4R)-4-formyl-2-oxo-1,3-oxazinan-3-yl]heptanoate In toluene at -78℃; for 1h;
Stage #3: With hydrogenchloride In water; toluene
(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

(S)-methyloxazaborolidine

(S)-methyloxazaborolidine

Conditions
ConditionsYield
With dimethylsulfide borane complex In toluene at 20℃; for 0.5h;
1-(4′-fluoro[1,1′-biphenyl]-2-yl)ethan-1-one
552885-75-3

1-(4′-fluoro[1,1′-biphenyl]-2-yl)ethan-1-one

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

A

C14H13FO

C14H13FO

B

C14H13FO

C14H13FO

Conditions
ConditionsYield
Stage #1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole With borane-THF In tetrahydrofuran at -30℃; for 1h; Inert atmosphere;
Stage #2: 1-(4′-fluoro[1,1′-biphenyl]-2-yl)ethan-1-one In tetrahydrofuran at -30℃; for 1h; Overall yield = 86 %; Overall yield = 1.8 g;
A n/a
B n/a

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