392311-87-4

Basic information

• Product Name: 4-chloro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide
• Synonyms: 4-chloro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide
• CAS NO: 392311-87-4
• Molecular Weight: 375.814
• Mol File: 392311-87-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide(392311-87-4)
• EPA Substance Registry System: 4-chloro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide(392311-87-4)

Safety Data

• Hazardous Substances Data: 392311-87-4(Hazardous Substances Data)

Upstream product

• 6781-65-3 N'-benzoyl-4-nitrobenzohydrazide 
• 93-89-0 benzoic acid ethyl ester 
• 53338-48-0 4-(5-phenyl-1,3,4-oxadiazole-2-yl)benzenamine 
• 122-01-0 4-chloro-benzoyl chloride 

Relevant articles and documents

Design, synthesis and biological evaluation of some oxadiazole derivatives as novel amide-based inhibitors of soluble epoxide hydrolase

Soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of endogenous chemical mediators which are involved in the regulation of blood pressure and inflammation. Although the most reported potent sEH inhibitors are urea derivatives, these compounds have limited pharmacokinetic profile. In order to improve physicochemical properties, besides having favorable potency, amide non-urea derivatives with oxadiazole ring as a novel secondary pharmacophore against sEH enzyme were developed. Most of the novel compounds with appropriate physical properties, had comparable in vitro sEH inhibitory activity to 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid (AUDA), a potent urea-based sEH inhibitor. The IC50value of the most potent compound (15c) was 0.43 nM.