53338-48-0Relevant academic research and scientific papers
The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)
Alavinia, Sedigheh,Ghorbani-Vaghei, Ramin
, p. 29728 - 29740 (2021/10/06)
Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.
Catalytic application of electrochemically prepared nickel oxide nanoparticles to synthesize 2, 5–disubstituted-1,3,4–oxadiazoles
Dare, Sushama B.,Gaikwad, Suresh T.,Rajbhoj, Anjali S.,Sawant, Manisha R.
, p. 300 - 308 (2020/07/03)
The present work aims to synthesize 2,5–disubstituted-1,3,4–oxadiazoles using electrochemically prepared nanoparticles of nickel oxide as catalyst.The nanoparticles thus prepared using electrochemical syntheses are in appreciable yield.The tetrabutyl phosphonium bromide has been used for capping followed by UV, FTIR, XRD, SEM EDS andTEM SAED studies for the characterization. The 2,5-disubstituted-1,3,4-oxadiazoles were synthesized from substituted benzoic acids and their hydrazides in microwave synthesis system using prepared nanoparticles as a catalyst.
Design, synthesis and biological evaluation of some oxadiazole derivatives as novel amide-based inhibitors of soluble epoxide hydrolase
Rezaee, Elham,Hedayati, Mahdi,Rad, Laleh Hoghooghi,Kiani, Azin,Shahhosseini, Soraya,Faizi, Mehrdad,Tabatabai, Sayyed Abbas
, p. 721 - 730 (2014/07/07)
Soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of endogenous chemical mediators which are involved in the regulation of blood pressure and inflammation. Although the most reported potent sEH inhibitors are urea derivatives, these compounds have limited pharmacokinetic profile. In order to improve physicochemical properties, besides having favorable potency, amide non-urea derivatives with oxadiazole ring as a novel secondary pharmacophore against sEH enzyme were developed. Most of the novel compounds with appropriate physical properties, had comparable in vitro sEH inhibitory activity to 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid (AUDA), a potent urea-based sEH inhibitor. The IC50value of the most potent compound (15c) was 0.43 nM.
Structural effect on controllable resistive memory switching in donor-acceptor polymer systems
Wang, Kun-Li,Liu, Gang,Chen, Po-Hao,Pan, Liang,Tsai, Hsin-Luen
, p. 322 - 336 (2014/01/06)
Controllable bistable electrical conductivity switching behavior and resistive memory effects have been demonstrated in Al/polymer/indium-tin oxide (ITO) sandwich structure devices, constructed from non-conjugated vinyl copolymers of PTPAnOXDm with pendant donor-acceptor chromophores. The observed electrical bistability can be attributed to the field-induced intra- and intermolecular charge transfer interaction between triphenylamine electron donor (D) and oxadiazole electron acceptor (A) entities, and is highly dependent on the chemical structure of the copolymers. The vinyl copolymers showed different memory behaviors, which depended on the loading of D/A ratios. The polymers containing only donor or acceptor moieties showed as insulators, the polymers containing both donor and acceptor moieties showed as WORM, flash and DRAM as D/A ratio increased. The structural effect on the physicochemical and electronic properties of the PTPAnOXDm copolymers, viz surface morphology, thermal stability, optical absorbance and photoluminescence, and molecular orbital energy levels, were investigated systematically to study the factors that influence the memory characteristics of the devices.
Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit
Brown, Matthew L.,Aaron, Wade,Austin, Richard J.,Chong, Angela,Huang, Tom,Jiang, Ben,Kaizerman, Jacob A.,Lee, Gary,Lucas, Brian S.,McMinn, Dustin L.,Orf, Jessica,Rong, Minqing,Toteva, Maria M.,Xu, Guifen,Ye, Qiuping,Zhong, Wendy,Degraffenreid, Michael R.,Wickramasinghe, Dineli,Powers, Jay P.,Hungate, Randall,Johnson, Michael G.
, p. 5206 - 5209 (2011/10/09)
A bis-amide antagonist of Smoothened, a seven-transmembrane receptor in the Hedgehog signaling pathway, was discovered via high throughput screening. In vitro and in vivo experiments demonstrated that the bis-amide was susceptible to N-acyl transferase mediated amide scission. Several bioisosteric replacements of the labile amide that maintained in vitro potency were identified and shown to be metabolically stable in vitro and in vivo.
Synthesis and biological evaluation of 1,3,4-oxadiazole derivatives as novel analgesic and antiinflammatory agents
Chavan,Nirmal,Bhosale
, p. 3919 - 3922 (2012/01/13)
A novel series of 4-(2-(4-(5-(4-substituted phenyl)-1,3,4-oxadiazol-2-yl) phenylamino)ethoxy)-2H-chromen-2-one (7a-j) have been synthesized from 4-(5-(4-substituted phenyl)-1,3,4-oxadiazol-2-yl)benzenamine (4a-j) and 4-(2-bromoethoxy)-2H-chromen-2-one (5). The synthesized compounds were characterized on the basis of their spectral (IR, 1H NMR) data and evaluated for the anti-inflammatory and analgesic activity by using different pharmacological models. The most active compounds were subjected to acute ulcerogenesis activity and were found to be less ulcerogenic than the standard.
17O NMR studies of substituted 1,3,4-oxadiazoles
Gierczyk, Blazej,Zalas, MacIej,Kazmierczak, Marcin,Grajewski, Jakub,Pankiewicz, Radoslaw,Wyrzykiewicz, Bozena
, p. 648 - 654 (2012/01/06)
Three series of substituted 1,3,4-oxadiazoles were studied by 17O NMR spectroscopy. Chemical shifts values were correlated with empirical Hammett parameters as well as calculated bond lengths and chemical shielding values.
Synthesis and antimicrobial activity of novel 1,3,4-oxadiazolyl-quinazolin- 4(3H)ones
Patel, Navin B.,Patel, Jaymin C.
experimental part, p. 923 - 931 (2010/11/04)
A series of 1,3,4-oxadiazolyl-quinazolin-4(3H)ones have been synthesized using known methods. All the compounds have been established on basis of elemental analysis, IR and NMR spectral data. The in vitro antimicrobial screening of the synthesized compounds were carried out against two gram-positive bacteria (S. aureus, S. pyogenes), two gram-negative bacteria (E. coli, P. aeruginosa), and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. The compounds 7d, 7g, 7l, 7o, 7p, and 7r possessed pronounced antibacterial activity whereas compound 7p exhibited promising antifungal activity.
A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides
Rajapakse, Hemaka A.,Zhu, Hong,Young, Mary Beth,Mott, Bryan T.
, p. 4827 - 4830 (2007/10/03)
A convenient one pot method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acids and acyl hydrazides is reported. Acid activation with CDI, followed by coupling with the desired acylhydrazide and dehydration in the same pot with Ph3P and CBr4 affords the corresponding 1,3,4-oxadiazoles in good yield. The scope of the acid and acylhydrazide components is presented.
