39235-57-9

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 24085-05-0 1-(3-chloromethyl-4-hydroxyphenyl)ethanone 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 

Downstream Products

• 57541-41-0 2-Methyl-benzoic acid 2-acetoxymethyl-4-(2-tert-butylamino-acetyl)-phenyl ester 
• 39235-60-4 4'-benzyloxy-3'-acetoxymethylacetophenone 
• 57540-94-0 2-Methyl-benzoic acid 2-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester 
• 57541-34-1 4-Methoxy-benzoic acid 2-acetoxymethyl-4-(2-tert-butylamino-acetyl)-phenyl ester 
• 57541-30-7 3-acetoxymethyl-4-(p-toluyloxy)-alpha-bromoacetophenone 
• 57541-33-0 4-Methoxy-benzoic acid 2-acetoxymethyl-4-(2-bromo-acetyl)-phenyl ester 
• 57541-29-4 3-acetoxymethyl-4-(p-toluyloxy)acetophenone 

Relevant academic research and scientific papers

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Esters of 3-(hydroxy or hydroxymethyl)-4-hydroxyphenyl aminomethyl ketones

Mono-, di- and tri-esters of 3-(hydroxy or hydroxymethyl)-4-hydroxy-alpha-(aminomethyl)benzyl alcohols, obtained by methods involving reduction of the corresponding mono- and di-ester ketones, are useful for producing sympathomimetic effects, such as bronchodilation, of long duration with low cardiovascular stimulating effect, in warm-blooded mammals.