39243-36-2Relevant academic research and scientific papers
Catalytic Asymmetric γ-Lactam Synthesis from Enolisable Anhydrides and Imines
Collar, Aarón Gutiérrez,Trujillo, Cristina,Lockett-Walters, Bruce,Twamley, Brendan,Connon, Stephen J.
, p. 7275 - 7279 (2019/05/15)
An anion-binding approach to the problem of preparing enantioenriched γ-lactams from enolisable anhydrides and imines is reported. A simple bisurea catalyst promotes the cycloaddition between α-aryl succinic anhydrides and either PMP- or benzhydryl-protec
The base-catalysed Tamura cycloaddition reaction: Calculation, mechanism, isolation of intermediates and asymmetric catalysis
Lockett-Walters, Bruce,Trujillo, Cristina,Twamley, Brendan,Connon, Stephen
, p. 11283 - 11286 (2019/09/30)
A combined experimental and computational investigation has revealed that the base-catalysed Tamura cycloaddition between homophthalic anhydride and activated alkenes/alkynes-a reaction previously thought of as a Diels-Alder type process-proceeds via a stepwise mechanism involving conjugate addition and ring closure; which allowed the first catalytic asymmetric α-substitution reactions to be demonstrated with up to >99% ee.
Catalytic, enantio- and diastereoselective synthesis of γ-butyrolactones incorporating quaternary stereocentres
Manoni, Francesco,Cornaggia, Claudio,Murray, James,Tallon, Sean,Connon, Stephen J.
, p. 6502 - 6504 (2012/07/31)
A new, highly enantio- and diastereoselective catalytic asymmetric formal cycloaddition of aryl succinic anhydrides and aldehydes which generates paraconic acid (γ-butyrolactone) derivatives is reported.
Electrocarboxylation of alkynes with carbon dioxide in the presence of metal salt catalysts
Li, Chuanhua,Yuan, Gaoqing,Jiang, Huanfeng
experimental part, p. 1685 - 1689 (2011/07/07)
With some common metal salts (CuI, FeCl3) as catalysts, alkynes can be effectively electrocarboxylated with CO2 (4 MPa) in an undivided cell with Ni cathode and Al sacrificial anode containing n-Bu4NBr-DMF as supporting el
Synthesis of diverse lactam carboxamides leading to the discovery of a new transcription-factor inhibitor
Ng, Pui Yee,Tang, Yuchen,Knosp, Wendy M.,Stadler, H. Scott,Shaw, Jared T.
, p. 5352 - 5355 (2008/03/27)
(Chemical Equation Presented) Diversity is the key: Skeletal diversity is a useful starting point in the search for compounds that modulate protein-biopolymer interactions. A library of 400 lactam carboxamides has been synthesized in a short synthetic sequence and a new compound that inhibits the interaction of a transcription factor (HOXA13) with its DNA target has been discovered, and inhibition of transcription is demonstrated in cells.
QUANTITATIVE DETERMINATION OF THE ELECTRONIC EFFECTS OF 3- AND 4-PYRIDAZINYL GROUPS FROM NMR SPECTRAL DATA FOR ISOMERIC AMINOPHENYL- AND PHENYLPYRIDAZINES
Shkurko, O. P.,Kuznetsov, S. A.,Denisov, A. Yu.,Mamaev, V. P.
, p. 763 - 770 (2007/10/02)
The previously unknown aminophenylpyridazines were synthesized.The inductive and resonance constants of 3- and 4-pyridazinyl groups were calculated on the basis of 1H and 13C NMR spectral data for isomeric aminophenyl- and phenylpyridazines in dimethyl sulfoxide (DMSO).
