3925-93-7

Basic information

• Product Name: 2-phenyl-3H-benzo[d]imidazol-5-ol
• Synonyms: 2-phenyl-3H-benzo[d]imidazol-5-ol
• CAS NO: 3925-93-7
• Molecular Weight: 210.235
• Mol File: 3925-93-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-phenyl-3H-benzo[d]imidazol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-3H-benzo[d]imidazol-5-ol(3925-93-7)
• EPA Substance Registry System: 2-phenyl-3H-benzo[d]imidazol-5-ol(3925-93-7)

Safety Data

• Hazardous Substances Data: 3925-93-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 96-96-8 4-methoxy-2-nitroaniline 
• 98-88-4 benzoyl chloride 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 69570-97-4 methyl 2-phenyl-1H-benzo[d]imidazole-6-carboxylate 
• 36692-49-6 Methyl 3,4-diaminobenzoate 
• 93053-63-5 5-ethoxy-2-phenyl-1⁽³⁾H-benzimidazole 
• 79877-53-5 5-methoxy-2-phenyl-1H-benzimidazole 
• 903751-98-4 N-(2-amino-5-methoxyphenyl)benzamide 
• 885-81-4 N-(4-ethoxy-2-nitrophenyl)acetamide 
• 616-86-4 2-nitro-4-ethoxyaniline 
• 1197-37-1 4-ethoxy-benzene-1,2-diamine 

Downstream Products

• 1370000-07-9 C₁₈H₁₉N₃O 
• 893772-64-0 C₁₉H₂₁N₃O 
• 1370000-10-4 C₁₈H₁₉N₃O₂ 
• 1370000-13-7 C₁₉H₂₂N₄O 
• 1370000-09-1 C₁₇H₁₉N₃O 
• 1370000-11-5 C₂₅H₂₅N₃O 
• 1370000-12-6 C₁₆H₁₇N₃O 
• 1370000-08-0 C₁₉H₂₁N₃O 
• 131336-31-7 4,6-Dinitro-2-(4-nitro-phenyl)-1H-benzoimidazol-5-ol 
• 131336-30-6 4,6-Dinitro-2-phenyl-1H-benzoimidazol-5-ol 
• 131336-27-1 5-Hydroxy-2-phenyl-1H-benzoimidazole-4-sulfonic acid 
• 131336-29-3 4-Nitro-2-phenyl-1H-benzoimidazol-5-ol 

Relevant articles and documents

Design, synthesis and biological evaluation of 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles as inhibitors of ebola virus infection

Novel 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles were designed and synthesized as Ebola virus inhibitors. The proposed structures of the new prepared benzimidazole-piperidine hybrids were confirmed based on their spectral data and CHN analyses. The target compounds were screened in vitro for their anti-Ebola activity. Among tested molecules, compounds 26a (EC50=0.93 μM, SI = 10) and 25a (EC50=0.64 μM, SI = 20) were as potent as and more selective than Toremifene reference drug (EC50 = 0.38 μM, SI = 7) against cell line. Data suggests that the mechanism by which 25a and 26a block EBOV infection is through the inhibition of viral entry at the level of NPC1. Furthermore, a docking study revealed that several of the NPC1 amino acids that participate in binding to GP are involved in the binding of the most active compounds 25a and 26a. Finally, in silico ADME prediction indicates that 26a is an idealy drug-like candidate. Our results could enable the development of small molecule drug capable of inhibiting Ebola virus, especially at the viral entry step.

Method for catalytically synthesizing benzimidazole compound by organic protonic acid under condition of no solvent

The invention discloses a method for catalytically synthesizing a benzimidazole compound by organic protonic acid under the condition of no solvent. According to the method provided by the invention,high efficiency catalysis is carried out to rapidly prep

Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives

A series of 2-arylbenzimidazole derivatives (3a-3p and 4a-4i) were synthesized and evaluated as potential antioxidant and antimicrobial agents. Their antioxidant properties were evaluated by various in vitro assays including hydroxyl radical (HO) scavenging, superoxide radical anion (O2 -) scavenging, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, and ferric reducing antioxidant power. Results demonstrated that compounds with hydroxyl group at the 5-position of benzimidazole ring had a comparable or better antioxidant activity in comparison to standard antioxidant tert-butylhydroquinone (TBHQ). Markedly, compound 4h that showed the highest HO scavenging activity (EC50 = 46 μM) in vitro had a significant reduction of 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced intracellular oxidative stress and H2O2-induced cell death. In addition, these compounds showed moderate to good inhibitory activity against Staphylococcus aureus selectively at noncytotoxic concentrations.