Application of Rh-catalyzed cyclization to the formation of a chiral quaternary carbon

Article abstract of DOI:10.1248/cpb.48.1822

Rh-Catalyzed cyclization was applied to the formation of a chiral quaternary carbon. It has become clear that the Rh-complex can discriminate between isopropenyl and 2-isopentenyl (or isopentyl) substituents, and the cyclization afforded 3,3,4-trisubstituted cyclopentanones with a chiral quaternary carbon in a stereoselective manner. The cyclization of 4-pentenals 6a, b by an achiral neutral Rh(PPh₃)₃Cl afforded 3,3,4-cis-trisubstituted cyclopentanones (±)-7a, b in 86-96%, and the cyclization by a cationic Rh[(R)-BINAP]ClO₄ afforded 3,3,4-trans-trisubstituted cyelopentanones (-)-8a, b of 82-86% ee in 88-98% yields. The mechanism of stereoselection by Rh-complexes is also discussed.

Full text of DOI:10.1248/cpb.48.1822

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NII-Electronic Library Service