39274-35-6

Upstream product

• 253185-03-4 tert-butylbenzene 
• 18369-83-0 methyl thiochloroformate 
• 72207-52-4 4-tert-Butyl-thiobenzoesaeure 
• 74-88-4 methyl iodide 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 5925-68-8 (S)-methyl thiobenzoate 
• 121149-70-0 1-[4-(1,1-dimethylethyl)phenyl]-2-phenylethanone 
• 2432-51-1 ethylthioacetic acid methyl ester 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 201230-82-2 carbon monoxide 
• 34047-39-7 4-methylsulfanyl-2-butanone 
• 52436-75-6 (4-tert-butylphenyl)diazonium tetrafluoroborate 
• 769-92-6 4-tert-Butylaniline 
• 35779-04-5 1-tert-butyl-4-iodobenzene 

Downstream Products

• 5925-68-8 (S)-methyl thiobenzoate 
• 121149-70-0 1-[4-(1,1-dimethylethyl)phenyl]-2-phenylethanone 
• 184477-20-1 1-[4-(1,1-dimethylethyl)phenyl]-2-(4-methoxyphenyl)ethanone 
• 727722-43-2 4-[2-[4-(1,1-dimethylethyl)phenyl]-2-oxoethyl]benzonitrile 
• 86211-08-7 S-methyl nonanethioate 
• 727722-44-3 1-[4-(1,1-dimethylethyl)phenyl]-2-(4-chlorophenyl)ethanone 
• 1387574-30-2 ethyl 4-[2-[4-(1,1-dimethylethyl)phenyl]-2-oxoethyl]benzoate 

Relevant academic research and scientific papers

Palladium Catalyzed Direct Carbonylative Thiomethylation of Aryldiazonium Salts and Amines with 4-(Methylthio)-2-Butanone as (Methylthio) Transfer Agent

Herein, an interesting palladium-catalyzed procedure for the direct carbonylative thiomethylation of aromatic amine derivatives with 4-methylthio-2-butanone is developed. Using 4-methylthio-2-butanone as (methylthio) transfer agent, a variety of corresponding thioesters are obtained with moderate to good yields under base-free condition. In addition, good functional group tolerance can be observed.

Palladium-catalyzed intermolecular transthioetherification of aryl halides with thioethers and thioesters

Functional group transfer reactions are an important synthetic tool in modern organic synthesis. Herein, we developed a new palladium-catalyzed intermolecular transthioetherification reaction of aryl halides with thioethers and thioesters. The synthetic utility and practicality of this catalytic protocol are demonstrated in a wide range of successful transformations (>70 examples). This catalytic protocol is applicable in carbonylative coupling processes as well, and the first example of carbonylative methylthioesterification of aryl halides has been achieved. Notably, this work also provides an approach to using natural products, such as methionine and selenomethionine, as the functional group sources.

Rhodium-catalyzed acyl-transfer reaction between benzyl ketones and thioesters: Synthesis of unsymmetric ketones by ketone CO-C bond cleavage and intermolecular rearrangement

In the presence of catalytic amounts of RhH(CO)(PPh3) 3 and 1,2-bis(diphenylphosphino)benzene (dppBz), acyl groups were transferred between benzyl ketones and thioesters/aryl esters. The rhodium complex catalyzed the cleavage of keto