394-52-5

Basic information

• Product Name: PENTAFLUOROETHYL PHENYL KETONE
• Synonyms: 2,2,3,3,3-PENTAFLUOROPROPIOPHENONE;PENTAFLUOROPRONANOYLBENZENE;PENTAFLUOROETHYL PHENYL KETONE;PENTAFLUOROETHYL PHENYL KETONE TECH;Pentafluoroethyl phenyl ketone 97%;Pentafluoroethylphenylketone97%;Pentafluoropropiophenone;(2,2,3,3,3-Pentafluoro-1-oxopropyl)benzene
• CAS NO: 394-52-5
• Molecular Formula: C₉H₅F₅O
• Molecular Weight: 224.13
• Mol File: 394-52-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 160-161°C
• Flash Point: 62.7ºC
• Appearance: /
• Density: 1,372 g/cm3
• CAS DataBase Reference: PENTAFLUOROETHYL PHENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: PENTAFLUOROETHYL PHENYL KETONE(394-52-5)
• EPA Substance Registry System: PENTAFLUOROETHYL PHENYL KETONE(394-52-5)

Safety Data

• Hazard Codes: F
• Statements: 10
• Safety Statements: 16
• RIDADR: 1993
• HazardClass: FLAMMABLE
• Hazardous Substances Data: 394-52-5(Hazardous Substances Data)

Usage

General Description

Pentafluoroethyl Phenyl Ketone is a chemical compound belonging to the family of Aryl and Aralkyl Ketones. Known for its aromatic nature, this chemical compound is often utilized in various industrial applications including pharmaceuticals and organic synthesis. It is characterized by the presence of fluorine atoms and a ketone functional group in its structure. However, detailed information about its properties such as toxicity, reactivity, and environmental impact is not readily available, suggesting it is not a commonly used or widely studied compound. Like any other chemical, it should be handled with appropriate safety measures to prevent possible health hazards.

Upstream product

• 60-29-7 diethyl ether 
• 422-64-0 pentafluoropropionic acid 
• 591-51-5 phenyllithium 
• 354-64-3 Pentafluoroethyl iodide 
• 93-89-0 benzoic acid ethyl ester 
• 422-59-3 2,2,3,3,3-pentafluoropropionyl chloride 
• 71-43-2 benzene 
• 98-88-4 benzoyl chloride 
• 116-14-3 polytetrafluoroethylene 
• 455-32-3 benzoyl fluoride 
• 887144-97-0 Togni's reagent 
• 86340-78-5 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene 
• 887144-94-7 Togni's reagent II 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 158388-64-8 Benzyl-[2,2,3,3,3-pentafluoro-1-phenyl-prop-(E)-ylidene]-amine 
• 1025829-97-3 C₂₀H₁₀F₁₀ 
• 1025829-97-3 (E)-1,1,1,2,2,7,7,8,8,8-decafluoro-3,6-diphenyl-3,4,5-octatriene 
• 1160937-01-8 2,2,3,3,3-pentafluoro-1-(1H-indole-3-yl)-1-phenylpropan-1-ol 
• 1265324-75-1 2-fluoro-2-(trifluoromethyl)-1-phenylhexane-1,5-dione 
• 1214364-82-5 6-(trifluoromethyl)biphenyl-3-ol 
• 74031-42-8 (3,3,3-trifluoroprop-1-enyl)benzene 
• 1579-80-2 (3,3,3-trifluoropropyl)benzene 
• 24165-19-3 {1-[1-Chloro-1-fluoro-meth-(Z)-ylidene]-2,2,3,3,3-pentafluoro-propyl}-benzene 
• 24165-18-2 {1-[1-Chloro-1-fluoro-meth-(E)-ylidene]-2,2,3,3,3-pentafluoro-propyl}-benzene 
• 5300-25-4 2-phenylperfluorobutene-1 
• 345-40-4 2,2,3,3,3-Pentafluoro-1-phenyl-propan-1-ol 

Relevant articles and documents

CsF-Catalyzed Fluoroacylation of Tetrafluoroethylene Using Acyl Fluorides for the Synthesis of Pentafluoroethyl Ketones

A catalytic method for the synthesis of pentafluoroethyl ketones has been developed. The cesium fluoride catalyst can be used to convert acyl fluorides into the pentafluoroethyl ketones under tetrafluoroethylene pressure without generating stoichiometric

Well-defined CuC2F5 complexes and pentafluoroethylation of acid chlorides

Four new well-defined CuI complexes bearing a C2F5 ligand have been prepared and fully characterized: [(Ph3P)2CuC2F5] (2), [(bpy)CuC2F5] (3), [(Ph3P)Cu(phen)C2F5] (4), and [(IPr)CuC2F5] (5). X-ray structures of all four have been determined, showing that the C2F5-ligated Cu atom can be di- (5), tri- (2 and 3), and tetracoordinate (4). The mixed phen-PPh3 complex 4 is a highly efficient fluoroalkylating agent for a broad variety of acid chlorides. This high-yielding transformation represents the first general method for the synthesis of RCOC2F5 from the corresponding RCOCl. Four well-defined CuC2F5 complexes have been prepared and fully characterized, with [(phen)Cu(PPh3)C2F5] (phen=1,10-phenanthroline) proving to be a remarkably efficient fluoroalkylating agent for a broad variety of acid chlorides (see scheme). The procedure represents the first general method for the one-step conversion of RCOCl into valuable pentafluoroethyl ketones.

A new entry for the oxidation of fluoroalkyl-substituted methanol derivatives: Scope and limitation of the organoiodine(V) reagent-catalyzed oxidation

Oxidation of various fluoroalkyl-substituted methanol derivatives under the influence of a catalytic amount of sodium 2-iodobenzenesulfonate and Oxone in CH3CN or CH3NO2 was investigated in detail. The efficiency of the newly developed oxidation was also evaluated by comparison to other oxidations, such as Dess-Martin, PDC, and Swern oxidation.