394231-40-4

Upstream product

• 956-02-5 4'-chlorochalcone 
• 109-77-3 malononitrile 
• 100-52-7 benzaldehyde 
• 3111-60-2 2-[1-(4-chlorophenyl)ethylidene]malononitrile 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1610049-44-9 (E)-ethyl 2-amino-5-benzylidene-4-(4-chlorophenyl)-3-cyanocyclopenta-1,3-diene-1-carboxylate 
• 1610049-29-0 (E)-diethyl 2-benzylidene-3-(4-chlorophenyl)-4-cyano-5-iminocyclopent-3-ene-1,1-dicarboxylate 
• 105387-95-9 2-amino-4-(4-chloro-phenyl)-6-phenyl-pyridine-3-carbonitrile 
• 1449136-06-4 C₃₁H₂₇ClN₂O₂ 

Relevant academic research and scientific papers

Synthesis and evaluation of novel 4H-pyrazole and thiophene derivatives derived from chalcone as potential anti-proliferative agents, Pim-1 kinase inhibitors, and PAINS

The chalcone derivatives 3a-d reacted with either malononitrile or ethyl cyanoacetate in ethanol in the presence of catalytic amount of ammonium acetate in an oil bath at 120°C to give the Knowevenagel condensation products 5a-h. The latter compounds reac

[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: A synthetic route to multi-substituted 2-aminopyridines

A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves

Phosphine-catalyzed annulations between modified allylic derivatives and polar dienes and substituent effect on the annulation mode

In this work, the phosphine-catalyzed annulation reactions between modified allylic derivatives and polar 1,1-dicyano-1,3-dienes have been studied. In the catalysis of PPh3 (20 mol%), a [4+1] annulation reaction is realized between a series of 1,1-dicyano-2,4-diaryl-1,3-dienes and ethoxycarbonyl- activated allylic acetate, producing polysubstituted cyclopentenes in modest to excellent yields. It is also observed that the substituents of both 1,3-dienes and allylic derivatives have a significant influence on the annulation mode: under the catalysis of PPh3 or PBu3 (20 mol%), regioselective [3+2] annulation products are formed from differently substituted substrates. Chemoselective phosphine-catalyzed [4+1] and [3+2] annulations of modified allylic derivatives and polar 1,3-dienes have been realized, and substituent effect on the annulation mode was first observed. Copyright