395-23-3

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)BENZHYDROL
• Synonyms: 4-(TRIFLUOROMETHYL)BENZHYDROL;PHENYL-(4-TRIFLUOROMETHYL-PHENYL)-METHANOL;4-(Trifluoromethyl)benzhydrol,97%;4-(trifluoromethyl)diphenylmethanol;phenyl 4-(trifluoromethyl)phenyl carbinol;4-(Trifluoromethyl)benzhydrol 97%;4-(triflouromethyl)benzhydrol;Phenyl[4-(trifluoromethyl)phenyl]methanol, 4-[Hydroxy(phenyl)methyl]benzotrifluoride, Phenyl 4-(trifluoromethyl)phenyl carbinol
• CAS NO: 395-23-3
• Molecular Formula: C₁₄H₁₁F₃O
• Molecular Weight: 252.23
• EINECS: 209-917-2
• Mol File: 395-23-3.mol
• Article Data: 54

Chemical Properties

• Melting Point: 59 °C
• Boiling Point: 122 °C
• Flash Point: 122-124°C/0.4mm
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 7.67E-05mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• BRN: 2127184
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)BENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)BENZHYDROL(395-23-3)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)BENZHYDROL(395-23-3)

Safety Data

• Hazard Codes: F
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1224
• HazardClass: FLAMMABLE
• Hazardous Substances Data: 395-23-3(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)Benzhydrol is a chemical substance often used in scientific research. 4-(TRIFLUOROMETHYL)BENZHYDROL belongs to the category of organofluorines, and is a more specific type of benzhydrol. The trifluoromethyl group (CF3) in its structure makes this compound organofluorine, indicating the presence of a carbon-fluorine bond. The presence of this trifluoromethyl group can potentially alter the compound’s reactivity, polarity and size, influencing its chemical properties and behaviors. Note some considerable potentials of usage such as pharmaceuticals or material science applications, however, these require further research.

InChI:InChI=1/C14H11F3O/c15-14(16,17)12-8-6-11(7-9-12)13(18)10-4-2-1-3-5-10/h1-9,13,18H

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 780-69-8 triethoxyphenylsilane 
• 416839-38-8 4-trifluoromethylphenylboronic acid 1,3-propanediol ester 
• 100-52-7 benzaldehyde 
• 1623-99-0 phenyl sodium 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 728-86-9 phenyl[4-(trifluoromethyl)phenyl]methanone 
• 591-50-4 iodobenzene 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 74289-72-8 p-(trifluoromethyl)benzaldehyde dimethyl acetal 
• 100-58-3 phenylmagnesium bromide 
• 909413-25-8 6-(tert-butyl)-12-phenyl-5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine 
• 1218-90-2 4-(trichloromethyl)-benzophenone 

Downstream Products

• 3216-17-9 4-[2-(4-trifluoromethyl-benzhydryloxy)-ethyl]-morpholine 
• 851-82-1 2-Dimethylamino-aethoxy-<4-trifluormethyl-benzhydryl> 
• 1032582-93-6 4-methyl-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)benzenesulfonamide 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 728-86-9 phenyl[4-(trifluoromethyl)phenyl]methanone 
• 846-91-3 1-((2-bromoethoxy)(phenyl)methyl)-4-(trifluoromethyl)benzene 
• 183317-03-5 ((4-(trifluoromethyl)phenyl)methylene)dibenzene 
• 53756-61-9 (S)-phenyl-(4-trifluoromethyl-phenyl)-methanol 

Relevant articles and documents

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Herein, we report an efficient, tunable system for electrochemical reduction of ketones and phthalimides at room temperature without the need for stoichiometric external reductants. By utilizing NaN3 as the electrolyte and graphite felt as both the cathode and the anode, we were able to selectively reduce the carbonyl groups of the substrates to alcohols, pinacols, or methylene groups by judiciously choosing the solvent and an acidic additive. The reaction conditions were compatible with a diverse array of functional groups, and phthalimides could undergo one-pot reductive cyclization to afford products with indolizidine scaffolds. Mechanistic studies showed that the reactions involved electron, proton, and hydrogen atom transfers. Importantly, an N3/HN3 cycle operated as a hydrogen atom shuttle, which was critical for reduction of the carbonyl groups to methylene groups.

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