39513-27-4

Basic information

• Product Name: 2H-Benzimidazol-2-one,5-acetyl-1,3-dihydro-(9CI)
• Synonyms: 2H-Benzimidazol-2-one,5-acetyl-1,3-dihydro-(9CI);5-Acetyl-1H-benzo[d]imidazol-2(3H)-one;5-Acetyl-1,3-Dihydro-2H-Benzimidazol-2-One(WX626007);5-Acetyl-1,3-dihydro-benzoimidazol-2-one;5-ACETYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ON
• CAS NO: 39513-27-4
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.174
• Product Categories: BENZIMIDAZOLE
• Mol File: 39513-27-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 294-295 °C(Solv: ethanol, 95% (64-17-5))
• Boiling Point: 218.103°C at 760 mmHg
• Flash Point: 87.593°C
• Appearance: /
• Density: 1.271g/cm³
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.579
• PKA: 11.59±0.30(Predicted)
• CAS DataBase Reference: 2H-Benzimidazol-2-one,5-acetyl-1,3-dihydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazol-2-one,5-acetyl-1,3-dihydro-(9CI)(39513-27-4)
• EPA Substance Registry System: 2H-Benzimidazol-2-one,5-acetyl-1,3-dihydro-(9CI)(39513-27-4)

Safety Data

• Hazardous Substances Data: 39513-27-4(Hazardous Substances Data)

Usage

General Description

2H-Benzimidazol-2-one,5-acetyl-1,3-dihydro-(9CI) is a chemical compound with the molecular formula C10H10N2O2. It is a derivative of benzimidazole, a fused heterocyclic compound. This chemical has potential pharmaceutical applications, as it exhibits biological activities such as anti-inflammatory and analgesic properties. It may also have antifungal and antitumor effects. Additionally, it has been studied for its potential use in the treatment of inflammatory and autoimmune diseases. The compound's 5-acetyl substitution may contribute to its biological activity, making it a promising candidate for further research and development in the pharmaceutical industry.

InChI:InChI=1/C9H8N2O2/c1-5(12)6-2-3-7-8(4-6)11-9(13)10-7/h2-4H,1H3,(H2,10,11,13)

Upstream product

• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 75-36-5 acetyl chloride 
• 75-44-5 phosgene 
• 21304-39-2 1-(3,4-diaminophenyl)ethanone 

Downstream Products

• 64826-44-4 1.3-Dimethyl-5-acetyl-benzimidazolon 

Relevant articles and documents

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as potential potentiators of the chloride transport defect in cystic fibrosis

Background: Cystic fibrosis (CF) is the autosomal recessive disorder most common in Caucasian populations. It is caused by mutations in the cystic fibrosis transmembrane regulator protein (CFTR). CFTR is predominantly expressed at the apical plasma membra

FRIDEL-CRAFTS ACYLATION OF BENZIMIDAZOLIN-2-ONES WITH ALIPHATIC ACID CHLORIDES

The acylation of benzimidazolin-2-one and its 5,6-disubstituted derivatives with aliphatic acid chlorides in the presence of anhydrous aluminium chloride was studied.The corresponding 5(6)-acyl-, 5-R-6-acyl, and 5,6-dimethyl-4-acylbenzimidazolin-2-ones, the structures of which were confirmed by the results of elementary analysis and IR, PMR, and mass spectroscopy, were obtained.The yields of the acylation products depend on the electronic effects of the substituents in the benzene ring of the benzimidazolin-2-one on steric factors.