396-32-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
7-fluoroquinoline is utilized as a key building block for the development of various pharmaceuticals and agrochemicals. Its fluorinated quinoline structure endows it with distinctive properties that are valuable in the creation of new and effective compounds.
Used in Medicinal Chemistry and Drug Discovery:
In the field of medicinal chemistry, 7-fluoroquinoline serves as a crucial component in the design and synthesis of potential drug candidates. Its unique chemical properties facilitate the exploration of new therapeutic agents with improved pharmacological profiles.
Used in Antimicrobial and Antimalarial Drug Development:
7-fluoroquinoline has demonstrated antimicrobial and antimalarial activity, positioning it as a promising candidate for the development of novel antibiotics and antimalarial drugs. Its potential to combat resistant strains of bacteria and parasites makes it a valuable asset in the ongoing battle against infectious diseases.
Used in Organic Synthesis:
The versatile nature of 7-fluoroquinoline makes it a valuable chemical compound in organic synthesis. Its ability to be modified and incorporated into a wide range of molecular structures contributes to the advancement of chemical research and the discovery of new materials and compounds.

InChI:InChI=1/C9H6FN/c10-8-4-3-7-2-1-5-11-9(7)6-8/h1-6H

Upstream product

• 372-19-0 meta-fluoroaniline 
• 56-81-5 glycerol 
• 3054-95-3 acrylaldehyde diethyl acetal 

Downstream Products

• 939758-75-5 7-fluoro-1,2,3,4-tetrahydroquinoline 
• 225366-89-2 3-amino-7-fluoroquinoline 
• 225366-90-5 3-bromo-7-fluoro-quinoline 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

High efficiency microwave-assisted synthesis of quinoline from acrolein diethyl acetal and aniline utilizing Ni/Beta catalyst

A facile and solvent-free microwave-assisted approach to quinoline was developed by utilizing both acrolein diethyl acetal and aniline as reagents, firstly employing Ni/Beta zeolite as mild, ecofriendly and low-cost solid catalyst. As high as 83% yield of quinoline was quickly achieved at a short microwave time. The results indicated that the effect of Ni on Beta zeolite not only significantly promoted conversion of acrolein diethyl acetal to effective intermediate but also dramatically accelerated dehydrogenation rate of tetrahydroquinoline/dihydroquinoline to quinoline.

HOTf-catalyzed intermolecular hydroamination reactions of alkenes and alkynes with anilines

Herein, the intermolecular hydroamination of alkenes and alkynes with anilines catalyzed by HOTf under mild conditions has been developed. This reaction provides one of the simplest alkene and alkyne addition methods and is an alternative to metal-catalyzed reactions. At the same time, the intramolecular hydroamination of alkynes with anilines proceeds smoothly to obtain quinolines. We found that this strategy is efficient in building complex structures from simple starting materials in an environmentally benign fashion.

7-Dialkylamino-1-alkylquinolinium salts: Highly versatile and stable fluorescent probes

7-Dialkylamino- and 7-alkylsulfenyl-1-alkylquinolinium salts have been synthesized using a novel synthetic approach. The key intermediate, 7-fluoro-1-methylquinolinium iodide, was shown to possess high reactivity toward nitrogen and sulfur nucleophiles, a