939758-75-5

Basic information

• Product Name: 7-Fluoro-1,2,3,4-tetrahydroquinoline
• Synonyms: 7-Fluoro-1,2,3,4-tetrahydroquinoline
• CAS NO: 939758-75-5
• Molecular Formula: C9H10FN
• Molecular Weight: 151.1808032
• Mol File: 939758-75-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 232.8°C at 760 mmHg
• Flash Point: 94.6°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.0578mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 7-Fluoro-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Fluoro-1,2,3,4-tetrahydroquinoline(939758-75-5)
• EPA Substance Registry System: 7-Fluoro-1,2,3,4-tetrahydroquinoline(939758-75-5)

Safety Data

• Hazardous Substances Data: 939758-75-5(Hazardous Substances Data)

Usage

General Description

7-Fluoro-1,2,3,4-tetrahydroquinoline is a chemical compound with the molecular formula C9H10FN. It is a fluorinated derivative of tetrahydroquinoline, which is a heterocyclic compound commonly found in various natural products and pharmaceutical drugs. 7-Fluoro-1,2,3,4-tetrahydroquinoline has potential applications in medicinal chemistry and drug development due to its structural features and biological activities. Its fluorinated moiety can enhance the compound's pharmacokinetic properties and increase its binding affinity to target proteins, making it a valuable scaffold for the design of new drug candidates. Additionally, the presence of the fluorine atom can also introduce unique chemical reactivity and selectivity, expanding the compound's synthetic and pharmaceutical potential. Overall, 7-Fluoro-1,2,3,4-tetrahydroquinoline is a promising chemical entity with important implications for drug discovery and development.

InChI:InChI=1/C9H10FN/c10-8-4-3-7-2-1-5-11-9(7)6-8/h3-4,6,11H,1-2,5H2

Upstream product

• 364-78-3 2-nitro-4-fluoroaniline 
• 313545-72-1 2-chloro-4-fluorophenylboronic acid 
• 396-32-7 7-Fluoroquinoline 
• 100638-26-4 3-chloro-N-(3-fluoro-phenyl)-propionamide 
• 372-19-0 meta-fluoroaniline 
• 114417-35-5 7-fluoro-2,3-dihydro-1H-quinolin-4-one 
• 4590-52-7 7-fluoro-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Dehydrogenative and Redox-Neutral N-Heterocyclization of Aminoalcohols Catalyzed by Manganese Pincer Complexes

A new manganese catalyzed heterocyclization of aminoalcohols has been accomplished. A wide range of heterocycles were synthesized, including 1,2,3,4-tetrahydroquinolines, dihydroquinolinones, and 2,3,4,5-tetrahydro-1H-benzo[b]azepines. The reaction is performed under mild reaction conditions using air and moisture stable manganese catalysts. The desired heterocycles were obtained in good to excellent yields.

DIACYLGLYCEROL KINASE MODULATING COMPOUNDS

The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.