397-53-5

Usage

Heterocyclic compound

Consists of an imidazo[1,2-a]pyrimidine core substituted with a 4-fluorophenyl group This refers to the structure of the compound, which is made up of a ring of atoms with at least one nitrogen atom in the ring.

Potential pharmaceutical properties

Has been studied for its potential use as a building block in the synthesis of biologically active compounds This means that the compound has been researched for its possible use in creating other compounds that can have an effect on biological systems.

Potential applications in medicinal chemistry

Specifically in the development of new drugs for various diseases This indicates that the compound has been investigated for its possible use in creating new drugs to treat different medical conditions.

Upstream product

• 109-12-6 2-aminopyrimidine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 357952-79-5 1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 64454-33-7 2-(4-fluoro-phenyl)-3-nitroso-imidazo[1,2-a]pyrimidine 
• 134044-59-0 2-(4-Fluoro-phenyl)-3-nitro-imidazo[1,2-a]pyrimidine 
• 60472-17-5 4-(4-fluorophenyl)-1H-imidazol-2-ylamine 
• 60472-17-5 4-(4-fluoro-phenyl)-1⁽³⁾H-imidazol-2-ylamine 
• 878436-47-6 2-(4-fluorophenyl)imidazo[1,2-a]pyrimidine-3-carbaldehyde 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of imidazopyridine/imidazopyrimidine-benzimidazole conjugates as potential anticancer agents

A series of imidazopyridine/imidazopyrimidine-benzimidazole conjugates (11a-t) were synthesized and evaluated for their antiproliferative activity. All of these conjugates showed moderate to improved cytotoxic activity against the human cervical (Hela), l

Structure-activity relationship of 4(5)-aryl-2-amino-1 H -imidazoles, N 1-substituted 2-aminoimidazoles and imidazo[1,2- a ]pyrimidinium salts as inhibitors of biofilm formation by salmonella typhimurium and pseudomonas aeruginosa

A library of 112 4(5)-aryl-2-amino-1H-imidazoles, 4,5-diphenyl-2-amino-1H- imidazoles, and N1-substituted 4(5)-phenyl-2-aminoimidazoles was synthesized and tested for the antagonistic effect against biofilm formation by Salmonella Typhimurium and Pseudomo

Tandem [8 + 2] cycloaddition-[2 + 6 + 2] dehydrogenation reactions involving imidazo[1,2- a ]pyridines and imidazo[1,2- a ]pyrimidines

The reaction between benzynes and imidazo[1,2-a]pyridines (pyrimidines) to form benzo[a]imidazo[5,1,2-cd]indolizines and 2,3,9c-triazocyclopenta[j,k] fluorenes has been studied computationally and experimentally. It is found that these reactions take plac

Hypervalent iodine(III) sulfonate mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines in liquid PEG-400

PEG-400[poly(ethylene glycol-400)] is used as a "green" recyclable solvent in the one-pot synthesis of 2-arylimidazo[1,2-a]pyrimidines by reaction with ketones, [hydroxyl(2,4-dinitrobenzenesulfonyloxy)-iodo]benzene (HDNIB), and 2-aminopyrimidine. Signific

A facile [hydroxy(tosyloxy)iodo]benzene mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines and their conversion into 3-bromo-2- arylimidazo[1,2-a]pyrimidines

α-Tosyloxyketone 2, obtained through hypervalent iodine oxidation of enolizable ketones using [hydroxy(tosyloxy)iodo]benzene (HTIB) in acetonitrile, on treatment with 2-aminopyrimidine 3 generates regioselectively 2-arylimidazo[1,2-a]pyrimidine 6 which up

Synthesis of 2-arylimidazo[1,2-a]pyrimidines by the Chichibabin synthesis in ionic liquids

A series of 2-arylimidazo[1,2-a]pyrimidines has been synthesised in excellent yields by the Chichibabin synthesis in room temperature ionic liquids.

Hypervalent Iodine in Synthesis 93. A Facile Synthesis of 2-Substituted Imidazo[1,2-a]pyrimidines by Cyclocondensation of Alkynyl(phenyl)iodonium Salts and 2-Aminopyrimidine

Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts 1 with 2-aminopyrimidine 2 in chloroform under reflux for two hours in the presence of K2CO3 gave, after workup, the 2-substituted imidazo[1,2-a]pyrimidines 3 in moderate to good yields. A possible mechanism for the formation of 3 involves the intramolecular cyclization of the intermediate alkylidenecarbene 6.

Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.

Antifungal activity in vitro of some imidazopyrimidine derivatives

In regard to fungicidal activity of imidazole ring found in chemical compounds such as econazole, a series of 42 diversely substituted imidazopyrimidines was synthetized and examined for its antifungal activity in several species.