2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIMIDINE

Base Information

• Chemical Name: 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIMIDINE
• CAS No.: 397-53-5
• Molecular Formula: C12H8FN3
• Molecular Weight: 213.214
• Mol file: 397-53-5.mol

Synonyms:2-(4'-fluorophenoxy)ethanol;2-(p-fluorophenyl)furan;2-p-Fluorphenylfuran;2-(4-Fluor-phenyl)-imidazo[1,2-a]pyrimidin;Ethanol,2-(4-fluorophenoxy);2-(p-fluorophenyl)imidazo[1,2-a]pyrimidine;2-(4-fluorophenyl)furan;2-(4-fluorophenoxy)ethan-1-ol;2-(p-Fluorophenoxy)ethanol;2-(4-fluoro-phenyl)-imidazo[1,2-a]pyrimidine;

Chemical Property of 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIMIDINE

Chemical Property:

• PSA: 30.19000
• LogP: 2.53540

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Fluorophenyl)imidazo[1,2-A]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIMIDINE

There total 6 articles about 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-aminopyrimidine (109-12-6) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(p-fluorophenyl)imidazo[1,2-a]pyrimidine (397-53-5)

Guidance literature:

With sodium carbonate; N-butylpyridinium tetrafluoroborate; at 20 ℃; for 3h;

Reference yield: 78.0%

2-aminopyrimidine (109-12-6) + (4-fluoro-phenylethynyl)-phenyl-iodonium; toluene-4-sulfonate → 2-(p-fluorophenyl)imidazo[1,2-a]pyrimidine (397-53-5)

Guidance literature:

With potassium carbonate; In chloroform; for 2h; Heating;

DOI:10.1002/jhet.5570400526

Reference yield: 59.0%

2-aminopyrimidine (109-12-6) + 1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone (357952-79-5) → 2-(p-fluorophenyl)imidazo[1,2-a]pyrimidine (397-53-5)

Guidance literature:

In acetonitrile; for 6h; Heating;

upstream raw materials:

2-aminopyrimidine

2-bromo-4'-fluoroacetophenone

1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone

1-(4-fluorophenyl)ethanone

Downstream raw materials:

2-(4-fluoro-phenyl)-3-nitroso-imidazo[1,2-a]pyrimidine

2-(4-Fluoro-phenyl)-3-nitro-imidazo[1,2-a]pyrimidine

4-(4-fluorophenyl)-1H-imidazol-2-ylamine

4-(4-fluoro-phenyl)-1⁽³⁾H-imidazol-2-ylamine

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