39718-99-5Relevant articles and documents
N-(4-Nitro-benzo-yl)-N′-phenyl-hydrazine: a three-dimensional hydrogen-bonded framework
Wardell, James L.,Low, John N.,Glidewell, Christopher
, p. o334-o336 (2007)
In the title compound (systematic name: N-anilino-4-nitro-benzamide), C13H11N3O3, the mol-ecules are linked into a complex three-dimensional framework structure by a combination of two-centre N - H...O and C - H...O hydrogen bonds and a three-centre N - H
HYDRAZIDE DERIVATIVES AND THEIR SPECIFIC USE AS ANTIBACTERIAL AGENTS BY CONTROLLING ACINETOBACTER BAUMANNII BACTERIUM
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Page/Page column 41-42, (2020/09/08)
The present invention relates to compounds of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, their use as a drug, in particular as antibacterial agent, notablyforpreventingand/or treating disorders associa
A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles
Yavari, Issa,Khaledian, Omid
supporting information, p. 9150 - 9153 (2020/10/02)
N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is
Intramolecular Diels-Alder and [3+2] Cycloaddition Reactions in the One-Pot Synthesis of Epoxypyrrolo[3,4-g]indazoles
Alizadeh, Abdolali,Amir Ashjaee Asalemi, Kaveh,Halvagar, Mohammadreza
supporting information, p. 2936 - 2944 (2019/07/22)
A one-pot approach for the synthesis of epoxypyrrolo[3,4- g ]indazoles is presented. The first step was initiated by a three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and 2-furancarboxylic acid, and led to 1,3-dioxoepoxyisoindole, followed by the addition of hydrazonoyl chloride through a [3+2]-cycloaddition reaction in the second step. The key step in the formation of final compound involves a bicyclization strategy through intramolecular Diels-Alder (IMDA) reaction.
[3+2]-cycloaddition of in situ generated nitrile imines and acetylene for assembling of 1,3-disubstituted pyrazoles with quantitative deuterium labeling
Voronin, Vladimir V.,Ledovskaya, Maria S.,Gordeev, Evgeniy G.,Rodygin, Konstantin S.,Ananikov, Valentine P.
, p. 3819 - 3828 (2018/04/14)
A novel synthetic methodology for the preparation of 1,3-disubstituted pyrazoles from in situ generated nitrile imines and acetylene is reported. The reactions are performed in a simple two-chamber reactor. One part of the reactor is loaded with hydrazonoyl chloride precursors of active nitrile imine species and a base. The other part is used to generate acetylene from CaC2 and water. Partitioning of the reactants improves the yields of desired pyrazoles up to 99% and simplifies their isolation to a simple procedure of solvent evaporation. The approach requires no complex equipment and utilizes inexpensive, safe, and easy to handle calcium carbide as a starting material. A model deuterium incorporation is carried out according to the developed methodology, producing a series of novel 4,5-dideuteropyrazoles with excellent deuterium enrichment. Theoretical calculations on reaction mechanism and characterization of possible intermediate structures were performed.
Copper(ii)-catalyzed coupling reaction: An efficient and regioselective approach to N′,N′-diaryl acylhydrazines
Zhang, Ji-Quan,Huang, Gong-Bin,Weng, Jiang,Lu, Gui,Chan, Albert S. C.
supporting information, p. 2055 - 2063 (2015/03/05)
Using N′-aryl acylhydrazines as aryl donors, a novel copper(ii)-catalyzed homo-coupling reaction of N′-aryl acylhydrazines has been developed for the synthesis of N′,N′-diaryl acylhydrazines. We also provided a complementary procedure for the preparation of unsymmetrical diaryl acylhydrazines via cross-coupling reaction. These protocols featured mild reaction conditions, wide functional group tolerance and highly regioselective products. Control experiments indicated that this kind of coupling reaction might undergo a transient acyl diazene intermediate. This journal is
Synthesis and antifungal activities of New pyrazole derivatives via 1,3-dipolar cycloaddition reaction
Zhang, Chuan-Yu,Liu, Xing-Hai,Wang, Bao-Lei,Wang, Su-Hua,Li, Zheng-Ming
scheme or table, p. 489 - 493 (2011/02/21)
A series of cycloadducts - pyrazoles via 1,3-dipolar cycloaddition reactions of generated nitrilimines with N-(4-chloro-2-fluorophenyl)maleimide were described. The novel compounds synthesized were characterized by 1H NMR, MS, and elemental analysis. The fungicidal tests showed that most of the title compounds exhibit significant fungicidal activities against Corynespora cassiicola.
A Simple and Efficient Method for the Reduction of Azo Compounds
Zhang, Chang-Rui,Wang, Yu-Lu
, p. 4205 - 4208 (2007/10/03)
Reduction of azo compounds using hydrazine hydrate as reducant without catalyst is described, which proceeded smoothly in mild condition and did not pollute the environment.
Ketoken gem-dithiols and trithiones: Synthesis and study of the behavior towards dipole reagents; Synthesis of some nitrogen heteroaromatics
Zayed, Salem E.
, p. 7 - 13 (2007/10/03)
The behavior of ketoken gem-dithiols towards active methylene and methyl groups resulted in the formation of thiopyrano-dihydrocaumarine derivatives IIIa,b via cyclocondensation reaction between substituted 4-dihydrocyclohexanone Ia.b. N-phenylpyrazoline
PREPARATION OF HYDRAZIDES USING SILICON TETRACHLORIDE AS COUPLING AGENT
Kornet, Milton J.,Tita, Terence T.,Thio, Alan P.
, p. 1261 - 1274 (2007/10/02)
Silicon tetrachloride proved to be an effective reagent for the preparation of hydrazides from carboxylic acids.Yields were comparable to those obtained via N,N'-dicyclohexylcarbodiimide (DCC) and the procedure was used to synthesize some hydrazides which are difficult to obtain otherwise.
