20876-37-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(Benzyloxy)-2-methyl-3-nitrobenzene is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the creation of complex molecules with potential therapeutic properties.
Used in Chemical Synthesis:
In the chemical industry, 1-(Benzyloxy)-2-methyl-3-nitrobenzene is used as a starting material for the preparation of other organic compounds. It can be transformed into various derivatives, which can then be used in different applications, such as dyes, pigments, and other specialty chemicals.
Used in Research and Development:
1-(Benzyloxy)-2-methyl-3-nitrobenzene is also utilized in research and development laboratories for studying the properties and reactivity of similar compounds. Its synthesis and modification can provide valuable insights into the development of new materials and drugs.
For example, the result of 1-(Benzyloxy)-2-methyl-3-nitrobenzene is:

InChI:InChI=1/C14H13NO3/c1-11-13(15(16)17)8-5-9-14(11)18-10-12-6-3-2-4-7-12/h2-9H,10H2,1H3

Upstream product

• 5460-31-1 3-nitro-o-cresol 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 4837-88-1 6-methoxy-2-nitrotoluene 
• 83-42-1 6-chloro-2-nitrotoluene 
• 603-83-8 3-nitro-o-tolylamine 

Downstream Products

• 65361-82-2 3-benzyloxy-2-methyl-phenylamine 
• 20289-26-3 4-benzyloxy-1H-indole 
• 70261-41-5 2-(2-hydroxyethyl)-3-nitrophenyl benzyl ether 
• 871339-61-6 1,1-dimethylethyl 4-(3-{[2-(diethylamino)ethyl]oxy}-2-methylphenyl)piperazine-1-carboxylate 
• 871339-59-2 1,1-dimethylethyl 4-{2-methyl-3-[(phenylmethyl)oxy]phenyl}piperazine-1-carboxylate 
• 871464-78-7 N,N-diethyl-2-[(2-methyl-3-piperazin-1-ylphenyl)oxy]ethanamine 
• 871339-58-1 1-(3-(benzyloxy)-2-methylphenyl)piperazine 
• 871339-60-5 1,1-dimethylethyl 4-(3-hydroxy-2-methylphenyl)piperazine-1-carboxylate 
• 78283-29-1 2-benzyloxy-6-nitro-trans-β-dimethylaminostyrene 
• 669077-49-0 AG₀₃₅₀₂₉ 
• 850364-08-8 4-(benzyloxy)-1H-indazole 
• 13523-95-0 4-benzyloxy-3-dimethylaminomethylindole 
• 1464-11-5 4-benzyloxyindole-3-acetonitrile 
• 109249-04-9 2-(4-(benzyloxy)-1H-indol-3-yl)ethanamine 

Relevant academic research and scientific papers

Synthetic method of 4-hydroxyindole

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthetic method of 4-hydroxyindole. Aiming at the problems existing in industrial production of 4-hydroxyindole in the prior art, the technical scheme of the invention is as follows: the method comprises the following steps: (1) protecting hydroxyl in a compound 3 by using a protective group to obtaina compound 4; (2) reacting the compound 4 with N, N-dimethylformamide dimethyl acetal to obtain a compound 5; (3) mixing the compound 5 with NH2NH2.H2O and MeOH, and carrying out a reaction to obtaina compound 6; and (4) removing the protective group of the compound 6 to obtain 4-hydroxyindole. According to the method for synthesizing 4-hydroxyindole, the cost of starting materials is low, the reaction conditions in the synthesis process are mild, operation is convenient, aftertreatment is simple, and the yield is high.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.

Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.

KINASE MODULATORS AND METHODS OF USE

The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

SYNTHESIS OF 4-SUBSTITUTED INDOLES FROM o-NITROTOLUENES

A facile two- or three-step transformation of o-nitrotoluenes into 4-substituted indoles is described.Treatment of o-nitrotoluenes 1 with DMF acetal, or sometimes more advantageously with tris(N,N-dimethylamino)methane, affords β-(N,N-dimethylamino)styrenes 2 which are readily converted too-nitrophenylacetaldehyde semicarbazones 3 without isolation.Reduction of either 2 or 3 affords 4-substituted indoles 4.Use of the very insoluble semicarbazones results in vastly superior yields of 4 by minimizing completing bimolecular condensation reactions during reduction.This new procedure has been applied to efficiently and conveniently prepare a series of 4-substituted indoles 4.