20876-37-3

Basic information

• Product Name: 1-(Benzyloxy)-2-methyl-3-nitrobenzene
• Synonyms: O2NC6H3(CH3)OCH2C6H5;2-BENZYLOXY-6-NITROTOLUENE;1-BENZYLOXY-2-METHYL-3-NITROBENZENE;3-NITRO-2-METHYL PHENOL BENZYL ETHER;BENZYL 3-NITRO-O-TOLYL ETHER;Benzene, 2-Methyl-1-nitro-3-(phenylMethoxy)-
• CAS NO: 20876-37-3
• Molecular Formula: C₁₄H₁₃NO₃
• Molecular Weight: 243.26
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 20876-37-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 60-63 °C(lit.)
• Boiling Point: 382.238 °C at 760 mmHg
• Flash Point: 165.245 °C
• Appearance: Yellow to pale brown/Powder
• Density: 1.203 g/cm³
• Vapor Pressure: 1.05E-05mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(Benzyloxy)-2-methyl-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Benzyloxy)-2-methyl-3-nitrobenzene(20876-37-3)
• EPA Substance Registry System: 1-(Benzyloxy)-2-methyl-3-nitrobenzene(20876-37-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 20876-37-3(Hazardous Substances Data)

Usage

General Description

1-Benzyloxy-2-methyl-3-nitrobenzene may be used in the preparation of 1-[2-[2-(benzyloxy)-6-nitrophenyl]vinyl]pyrrolidine and 4-(benzyloxy)-1H-indole.

InChI:InChI=1/C14H13NO3/c1-11-13(15(16)17)8-5-9-14(11)18-10-12-6-3-2-4-7-12/h2-9H,10H2,1H3

Upstream product

• 4837-88-1 6-methoxy-2-nitrotoluene 
• 83-42-1 6-chloro-2-nitrotoluene 
• 100-39-0 benzyl bromide 
• 603-83-8 3-nitro-o-tolylamine 
• 5460-31-1 3-nitro-o-cresol 
• 100-44-7 benzyl chloride 

Downstream Products

• 39731-09-4 4-benzyloxylindole-2-carboxylic acid 
• 78283-29-1 2-benzyloxy-6-nitro-trans-β-dimethylaminostyrene 
• 669077-49-0 AG₀₃₅₀₂₉ 
• 850364-08-8 4-(benzyloxy)-1H-indazole 
• 70261-41-5 2-(2-hydroxyethyl)-3-nitrophenyl benzyl ether 
• 20289-26-3 4-benzyloxy-1H-indole 
• 65361-82-2 3-benzyloxy-2-methyl-phenylamine 
• 13523-95-0 4-benzyloxy-3-dimethylaminomethylindole 
• 1464-11-5 4-benzyloxyindole-3-acetonitrile 
• 109249-04-9 2-(4-(benzyloxy)-1H-indol-3-yl)ethanamine 
• 83788-94-7 4-benzyloxytryptamine hydrochloride 
• 83788-99-2 5-Benzyloxy-1,2-dimethyl-2,3,4,9-tetrahydro-1H-β-carboline 
• 83788-98-1 5-Benzyloxy-2-methyl-2,3,4,9-tetrahydro-1H-β-carboline 
• 83788-93-6 E-3-(2-nitrovinyl)-4-benzyloxyindole 

Relevant articles and documents

Synthetic method of 4-hydroxyindole

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthetic method of 4-hydroxyindole. Aiming at the problems existing in industrial production of 4-hydroxyindole in the prior art, the technical scheme of the invention is as follows: the method comprises the following steps: (1) protecting hydroxyl in a compound 3 by using a protective group to obtaina compound 4; (2) reacting the compound 4 with N, N-dimethylformamide dimethyl acetal to obtain a compound 5; (3) mixing the compound 5 with NH2NH2.H2O and MeOH, and carrying out a reaction to obtaina compound 6; and (4) removing the protective group of the compound 6 to obtain 4-hydroxyindole. According to the method for synthesizing 4-hydroxyindole, the cost of starting materials is low, the reaction conditions in the synthesis process are mild, operation is convenient, aftertreatment is simple, and the yield is high.

Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.