39748-15-7

Upstream product

• 44804-83-3 N-formyl-D,L-alanine methyl ester 
• 799779-64-9 methyl (2S)-2-isocyanopropanoate 
• 32221-83-3 (S)-N-formylalanine methyl ester 

Downstream Products

• 63348-62-9 N-Benzyl-2-isocyanpropionsaeureamid 
• 125294-68-0 Methyl 2-isocyano-2-<3-(trimethylsilyloxy)cyclohex-2-enyl>propionate 
• 125294-60-2 2-Isocyano-2-(3-oxo-cyclohexyl)-propionic acid methyl ester 
• 74531-03-6 1-Benzhydryl-4-methyl-2-oxoimidazolidin-4-carbonsaeure-methylester 
• 74531-04-7 1-Benzhydryl-4-methyl-2-oxoimidazolidin-4-carbonsaeure-tert-butylester 
• 28385-45-7 L-α-methylphenylalanine methyl ester 
• 38574-55-9 (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate 
• 64619-97-2 L-N-formyl-α-methylphenylalanine methyl ester 
• 64619-65-4 D,L-N-formyl-α-methylphenylalanine methyl ester 
• 120133-93-9 (4S,5R)-4-(methoxycarbonyl)-4-methyl-5-phenyl-2-oxazoline 
• 120133-93-9 (4R,5S)-4-(methoxycarbonyl)-4-methyl-5-phenyl-2-oxazoline 
• 120133-93-9 cis-4-(methoxycarbonyl)-4-methyl-5-phenyl-2-oxazoline 
• 74531-01-4 4-Methyl-2-oxo-1,5-diphenylimidazolidin-4-carbonsaeure-methylester 
• 1265831-06-8 2-(5-phenyl-1H-tetrazol-1-yl)propanoic acid methyl ester 

Relevant academic research and scientific papers

Chiral trans-carboxylic trifluoromethyl 2-imidazolines by a Ag2O-catalyzed Mannich-type reaction

Trifluoromethyl aldimines derived from α-amino esters have proven to be very good starting materials to obtain the title compounds. A Ag2O-catalyzed Mannich-type/cyclization cascade reaction starting from suitable α-isocyano acetates leads to e

Enantioselective synthesis of 1,2,4-triazolines by chiral iron(ii)-complex catalyzed cyclization of α-isocyano esters and azodicarboxylates

Enantioselective cyclization of α-isocyano esters with azodicarboxylates catalyzed by FeII-N,N′-dioxide complexes has been developed. Under mild conditions, a variety of 1,2,4-triazoline derivatives was obtained in high yields and enantioselectivities.

Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions

Isocyanoacetates are uniquely reactive compounds characterized by an ambivalent isocyano functional group and an enolizable α-carbon. It is widely believed that chiral α-substituted isocyanoacetates are configurationally unstable in some synthetically use

A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines

(Chemical Equation Presented) A multicomponent reaction between α-acidic isonitriles, primary amines, and carbonyl compounds was studied using 14 different solvents. Depending on the isocyanide that was used, optimal yields for the three-component synthesis of 2H-2-imidazolines were observed in different solvents. The solvents could be used as purchased, and in situ preformation of the imine was not required. By selecting the appropriate solvent, it was possible to considerably expand the range of compatible isocyanides toward less α-acidic isocyanides. Further process simplification was achieved by performing the reaction at higher concentrations and avoiding purification by column chromatography, resulting in a fast, easy to perform, and resource-efficient protocol for this three-component reaction.