44804-83-3Relevant academic research and scientific papers
Chiral trans-carboxylic trifluoromethyl 2-imidazolines by a Ag2O-catalyzed Mannich-type reaction
Trulli, Laura,Sciubba, Fabio,Fioravanti, Stefania
, p. 572 - 577 (2018/01/10)
Trifluoromethyl aldimines derived from α-amino esters have proven to be very good starting materials to obtain the title compounds. A Ag2O-catalyzed Mannich-type/cyclization cascade reaction starting from suitable α-isocyano acetates leads to e
The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids
Cerutti, Erika,Viale, Alessandra,Nervi, Carlo,Gobetto, Roberto,Aime, Silvio
, p. 11271 - 11279 (2015/12/01)
A series of dehydroamino acids endowed with different protective groups at the amino and carboxylate moieties and with different substituents at the double bond have been reacted with parahydrogen. The observed ParaHydrogen Induced Polarization (PHIP) effects in the 1H NMR spectra are strongly dependent on the amino protecting group. DFT calculations allowed us to establish a relationship between the structures of the reaction intermediates (whose energies depend on the amido substitution) and the observed PHIP patterns.
Enantioselective synthesis of 1,2,4-triazolines by chiral iron(ii)-complex catalyzed cyclization of α-isocyano esters and azodicarboxylates
Wang, Min,Liu, Xiaohua,He, Peng,Lin, Lili,Feng, Xiaoming
supporting information, p. 2572 - 2574 (2013/04/10)
Enantioselective cyclization of α-isocyano esters with azodicarboxylates catalyzed by FeII-N,N′-dioxide complexes has been developed. Under mild conditions, a variety of 1,2,4-triazoline derivatives was obtained in high yields and enantioselectivities.
A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines
Elders, Niels,Schmitz, Rob F.,De Kanter, Frans J. J.,Ruijter, Eelco,Groen, Marinus B.,Orru, Romano V. A.
, p. 6135 - 6142 (2008/02/10)
(Chemical Equation Presented) A multicomponent reaction between α-acidic isonitriles, primary amines, and carbonyl compounds was studied using 14 different solvents. Depending on the isocyanide that was used, optimal yields for the three-component synthesis of 2H-2-imidazolines were observed in different solvents. The solvents could be used as purchased, and in situ preformation of the imine was not required. By selecting the appropriate solvent, it was possible to considerably expand the range of compatible isocyanides toward less α-acidic isocyanides. Further process simplification was achieved by performing the reaction at higher concentrations and avoiding purification by column chromatography, resulting in a fast, easy to perform, and resource-efficient protocol for this three-component reaction.
A facile procedure for the synthesis of N-formyl amino acid esters
Chancellor,Morton
, p. 1023 - 1025 (2007/10/02)
A variety of amino acid ester hydrochlorides react with triethyl orthoformate (TEOF) or trimethyl orthoformate (TMOF) to give the N-formyl amino acid ester in good yield and high optical purity.
Trimethylacetic formic anhydride. Improved preparation and use as a highly efficient and selective N-formylating reagent
Vlietstra, Edward J.,Zwikker, Jan W.,Nolte, Roeland J. M.,Drenth, Wiendelt
, p. 460 - 462 (2007/10/02)
The title compound was prepared from trimethylacetyl chloride and sodium formate in the presence of 18-crown-6.The mixed anhydride proved to be a very useful reagent for the N-formylation of amines.Even amines which are unstable when deprotonated can be formylated.
