39767-89-0

Upstream product

• 1074-16-4 2-bromophenylethyl alcohol 
• 74-88-4 methyl iodide 
• 107-30-2 chloromethyl methyl ether 
• 18698-97-0 ortho-bromophenylacetic acid 
• 67-56-1 methanol 
• 15115-58-9 3-(2-bromophenyl)propionic acid 

Downstream Products

• 119367-72-5 2-(2-Methoxyethyl)benzyl alcohol 
• 68718-83-2 diphenyl o-(methoxyethyl)phenylphosphine oxide 
• 1122568-03-9 [2-(2-methoxyethyl)phenyl]boronic acid 
• 1438824-90-8 C₁₁H₁₈OSi 
• 1438827-63-4 C₉H₁₂O₃ 
• 1438827-40-7 C₁₅H₂₃BO₃ 
• 1438826-46-0 C₁₇H₂₉BO₃Si 
• 60835-86-1 2-(β-Methoxyethyl)-benzoesaeure-methyl-d3-ester 

Relevant academic research and scientific papers

MODULATORS OF HEMOGLOBIN

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.

Highly Selective Synthesis of Tetrahydronaphthaleno[60]fullerenes via Fullerene-Cation-Mediated Intramolecular Cyclization

A high-yielding protocol to construct six-membered carbon rings on fullerene is presented. This methodology with in situ fullerene-cation-mediated intramolecular cyclization provides high selectivity and efficient access to six-membered tetrahydronaphthal

Influence of the ortho-methoxyalkyl substituent on the properties of phenylboronic acids

Novel phenylboronic acids with methoxyalkyl groups at ortho position were synthesized. Molecular and crystal structures for two compounds were determined by single crystal X-ray diffraction. In both cases the O-H?O hydrogen-bonded dimers are the primary s

Iridium-catalyzed borylation of secondary benzylic C-H bonds directed by a hydrosilane

Most functionalizations of C-H bonds by main-group reagents occur at aryl or methyl groups. We describe a highly regioselective borylation of secondary benzylic C-H bonds catalyzed by an iridium precursor and 3,4,7,8-tetramethyl-1, 10-phenanthroline as the ligand. The reaction is directed to the benzylic position by a hydrosilyl substituent. This hydrosilyl directing group is readily deprotected or transformed to other functional groups after the borylation reaction, providing access to a diverse set of secondary benzylboronate esters by C-H borylation chemistry.

Identification of a new biaryl scaffold generating potent renin inhibitors

The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring such as

RENIN INHIBITORS

The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as wel

Amine- and ether-chelated aryllithium reagents - Structure and dynamics

Chelation and aggregation in phenyllithium reagents with potential 6- and 7-ring chelating amine (2, 3) and 5-, 6-, and 7-ring chelating ether (4, 5, 6) ortho substituents have been examined utilizing variable temperature 6Li and 13C NMR spectroscopy, 6Li and 15N isotope labeling, and the effects of solvent additives. The 5- and 6-ring ether chelates (4, 5) compete well with THF, but the 6-ring amine chelate (2) barely does, and 7-ring amine chelate (3) does not. Compared to model compounds (e.g., 2-ethylphenyllithium 7), which are largely monomeric in THF, the chelated compounds all show enhanced dimerization (as measured by K = [D]/[M]2) by factors ranging from 40 (for 6) to more than 200 000 (for 4 and 5). Chelation isomers are seen for the dimers of 5 and 6, but a chelate structure could be assigned only for 2-(2-dimethylaminoethyl)phenyllithium (2), which has an A-type structure (both amino groups chelated to the same lithium in the dimer) based on NMR coupling in the 15N, 6Li labeled compound. Unlike the dimer, the monomer of 2 is not detectably chelated. With the exception of 2-(methoxymethyl)phenyllithium (4), which forms an open dimer (12) and a pentacoordinate monomer (13), the lithium reagents all form monomeric nonchelated adducts with PMDTA.

Intramolecularly coordinated arylmagnesium compounds: effects on the Schlenk equilibrium

A series of phenylmagnesium bromides (1, 3-8) with ortho-substituents capable of forming intramolecular coordinative bonds along with the corresponding diarylmagnesium compounds (1a, 3a-6a, 8a) have been synthesized.The thermodynamic parameters ΔHs and ΔSs for the Schlenk equilibria (2 ArMgBr Ar2Mg + MgBr2) have been determined by variable temperature NMR spectroscopy.Crystal structures were obtained of 5,6,8,9-tetrahydrodibenzoxamagnesecin (2a) and bis(2,6-di(methoxymethyl)phenyl)magnesium (4a).The extent of intramolecular coordination in these compounds as determined in the solid state, is used in the discussion of the influence of substituents on the Schlenk equilibrium parameters.Unusual penta- or hexa-coordination is encountered and explained as a consequence of intramolecular coordination.

Substrate regulation of product distribution in the reactions of aryl chromium carbene complexes with alkynes

The reactions of arylcarbene complexes with alkynes were examined for six of the nine possible substitution patterns for mono- and dioxygenated aryl substituents of the carbene carbon. The product distributions were found to be highly dependent on a numbe