39786-34-0Relevant academic research and scientific papers
COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR
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Paragraph 0199, (2017/08/01)
The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.
COMPOUND FOR ORGANIC OPTOELECTRIC DEVICE, ORGANIC OPTOELECTRIC DEVICE AND DISPLAY DEVICE
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Paragraph 0101-0104, (2017/01/26)
The present invention relates to a compound for an organic photoelectronic device, the organic photoelectronic device comprising the same, and a display device comprising the organic photoelectronic device, wherein the compound for an organic photoelectronic device is represented by chemical formula 1. In the chemical formula 1, A1, A2, X, R1 to R5, L1 to L3 are the same as defined in the specification.
SUBSTITUTED TRICYCLIC PYRIDINE OR PYRIMIDINE VANILLOID RECEPTOR LIGANDS
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Page/Page column 28, (2009/07/25)
The present invention relates to substituted tricyclic compounds, which can be used as vanilloid receptor ligands. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by vanilloid receptor-1 (VRl). Also provided herein are pharmaceutical compositions and methods for treating or preventing diseases, conditions and/or disorders modulated by VRl.
Efficient iminophosphorane-mediated preparation of benzofuro-[3,2-d] pyrimidin-4(3H)-ones and unexpected ring opening products
Hu, Yang-Gen,Liu, Ming-Guo,Ding, Ming-Wu
scheme or table, p. 862 - 872 (2009/03/11)
The carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with secondary amines, phenols or alcohols in the presence of catalytic amounts of K2CO3 or sodium alkoxide to give 2-substituted benzofuro[3,2-d]pyrimidin-4(3H)-ones 6. However, when 2,2′-iminobis[ethanol] was used, the unexpected ring opening product 7 was formed instead of 6. Reaction of 4 with primary amines RNH2 (R = Et, Pr, Bu, etc.) gave guanidine intermediates 8, which were further treated with EtONa to give only one regioisomer 9 via a base catalyzed cyclization. However, another regioisomer 11 was obtained when NH3 or 'small' amines RNH2 (R = Me, NH2) were used in the absence of EtONa via a spontaneous cyclization of 8.
Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin
Sato, Shinichi,Tetsuhashi, Masashi,Sekine, Keiko,Miyachi, Hiroyuki,Naito, Mikihiko,Hashimoto, Yuichi,Aoyama, Hiroshi
, p. 4685 - 4698 (2008/12/20)
A series of hybrid compounds of bestatin (1) and actinonin (3), which promote degradation of cellular inhibitor of apoptosis protein 1 (cIAP1), were designed and synthesized. Structure-activity relationship studies indicated that absolute configuration, hydrophobicity at the α-position of the internal amide carbonyl group, and the presence of a small substituent at the α-position of the ester group are important factors for the expression of potent cIAP1 degradation-promoting activity. HAB-5A (30b) showed the most potent activity (IC50 = 0.53 μM) among the compounds prepared.
Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity
Ando, Kumiko,Tsuji, Eriko,Ando, Yuko,Kuwata, Noriko,Kunitomo, Jun-Ichi,Yamashita, Masayuki,Ohta, Shunsaku,Kohno, Shigekatsu,Ohishi, Yoshitaka
, p. 625 - 635 (2007/10/03)
Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.
