399-20-2 Usage
Uses
Used in Pharmaceutical Industry:
Benzothiazole, 2-Methyl-6-(trifluoroMethoxy)is used as a key intermediate in the development of new drugs. Its unique chemical structure allows for the creation of various pharmaceuticals with different therapeutic properties.
Used in Agrochemical Industry:
Benzothiazole, 2-Methyl-6-(trifluoroMethoxy)is also used in the development of new agrochemicals. Its potential biological activities make it a valuable component in the creation of effective pesticides and other agricultural products.
Used in Dye Industry:
Benzothiazole, 2-Methyl-6-(trifluoroMethoxy)is used as a crucial intermediate in the synthesis of various dyes. Its unique structure contributes to the production of dyes with specific color properties and applications.
Used in Organic Synthesis:
Due to its unique chemical structure, Benzothiazole, 2-Methyl-6-(trifluoroMethoxy)is an important intermediate in the synthesis of other organic compounds. It plays a vital role in the creation of a wide range of chemical products across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 399-20-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 399-20:
(5*3)+(4*9)+(3*9)+(2*2)+(1*0)=82
82 % 10 = 2
So 399-20-2 is a valid CAS Registry Number.
399-20-2Relevant academic research and scientific papers
Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The ‘fluorine-walk’ analysis
Lasing, Thitiya,Phumee, Atchara,Siriyasatien, Padet,Chitchak, Kantima,Vanalabhpatana, Parichatr,Mak, Kit-Kay,Hee Ng, Chew,Vilaivan, Tirayut,Khotavivattana, Tanatorn
, (2019/12/09)
In a search for potent antileishmanial drug candidates, eighteen rhodacyanine analogues bearing fluorine or perfluoroalkyl substituents at various positions were synthesized. These compounds were tested for their inhibitory activities against Leishmania martiniquensis and L. orientalis. This ‘fluorine-walk’ analysis revealed that the introduction of fluorine atom at C-5, 6, 5′, or 6′ on the benzothiazole units led to significant enhancement of the activity, correlating with the less negative reduction potentials of the fluorinated analogues confirmed by the electrochemical study. On the other hand, [sbnd]CF3 and [sbnd]OCF3 groups were found to have detrimental effects, which agreed with the poor aqueous solubility predicted by the in silico ADMET analysis. In addition, some of the analogues including the difluorinated species showed exceptional potency against the promastigote and axenic amastigote stages (IC50 = 40–85 nM), with the activities surpassing both amphotericin B and miltefosine.
